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10.1080/21541264.2016.1160173

http://scihub22266oqcxt.onion/10.1080/21541264.2016.1160173
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suck abstract from ncbi


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pmid27028424
      Transcription 2016 ; 7 (2 ): 44-9
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  • Telomerase reactivation in cancers: Mechanisms that govern transcriptional activation of the wild-type vs mutant TERT promoters #MMPMID27028424
  • Li Y ; Tergaonkar V
  • Transcription 2016[Mar]; 7 (2 ): 44-9 PMID27028424 show ga
  • Transcriptional activation of telomerase reverse transcriptase (TERT) gene is a rate-limiting determinant in the reactivation of telomerase expression in cancers. TERT promoter mutations represent one of the fundamental mechanisms of TERT reactivation in cancer development. We review recent studies that elucidate the molecular mechanisms underscoring activation of mutant TERT promoters.
  • |*Enzyme Activation [MESH]
  • |*Transcriptional Activation [MESH]
  • |Gene Expression Regulation, Neoplastic [MESH]
  • |Humans [MESH]
  • |Models, Biological [MESH]
  • |Mutation [MESH]
  • |Neoplasms/*enzymology/genetics [MESH]
  • |Promoter Regions, Genetic/*genetics [MESH]


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