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10.17305/bjbms.2016.721 http://scihub22266oqcxt.onion/10.17305/bjbms.2016.721 C4852991!4852991!26894286     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bosn+J+Basic+Med+Sci 2016 ; 16 (2): 108-13 Nephropedia Template TP {{tp|p=26894286|t=2016. LGALS3 and AXIN1 gene variants playing role in the Wnt/?-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer |pdf=|usr=}}{{26894286}} gab.com Text LGALS3 and AXIN1 gene variants playing role in the Wnt/ -catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer JO: Bosn J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=26894286 #FOAvip The Wnt pathway alterations have been identified in colorectal and many other cancer types. It has been reported that galectin-3 (which is encoded by the LGALS3 gene) alters the signaling mechanism in the Wnt/?-catenin pathway by binding to ?-catenin in colon and other cancers. AXIN1 is mainly responsible for the assembly of the ?-catenin destruction complex in the Wnt pathway. This study investigated the relationship of rs4644 and rs4652 variants of the LGALS3 gene and rs214250 variants of the AXIN1 gene to histopathological and clinical properties. Our study included a total of 236 patients, of whom 119 had colorectal cancer (42 women, 77 men) and 117 were healthy controls. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and allele-specific oligonucleotide (ASO) PCR methods were used. In addition, the serum galectin-3 level was studied with the enzyme-linked immunosorbent assay (ELISA) method. For the rs4644 variant of the LGALS3 gene, the CC genotype a mucinous component was significantly more common than those without a mucinous component (p=0.026). C allele frequency of the rs214250 variant of the AXIN1 gene was significantly correlated to tumor size in the advanced tumor stage (p=0.022). The CCAACT haplotype was more common in colorectal cancer patients (p=0.022). Serum galectin-3 level was higher in the patient group compared to the control group (5.9± 0.69 ng/ml vs. 0.79±0.01 ng/ml; p<0.001). In conclusion, variants of LGALS3 and AXIN1 genes affect tumor sizes and the mucinous component via Wnt/?-catenin pathway in the pathogenesis of colorectal cancer. Twit Text FOAVip LGALS3 and AXIN1 gene variants playing role in the Wnt/ -catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer ????Bosn J Basic Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=26894286 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26894286 #FOAvip English Wikipedia <ref>{{Cite pmid|26894286}}</ref> LGALS3 and AXIN1 gene variants playing role in the Wnt/?-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer #MMPMID26894286 Korkmaz G; Horozoglu C; Ar?kan S; Gural Z; Sa?lam EK; Turan S; Özkan NE; Kahraman OT; Yenilmez EN; Düzköylü Y; Do?an MB; Zeybek U; Ergen A; Yayl?m ? Bosn J Basic Med Sci 2016[May]; 16 (2): 108-13 PMID26894286show ga The Wnt pathway alterations have been identified in colorectal and many other cancer types. It has been reported that galectin-3 (which is encoded by the LGALS3 gene) alters the signaling mechanism in the Wnt/?-catenin pathway by binding to ?-catenin in colon and other cancers. AXIN1 is mainly responsible for the assembly of the ?-catenin destruction complex in the Wnt pathway. This study investigated the relationship of rs4644 and rs4652 variants of the LGALS3 gene and rs214250 variants of the AXIN1 gene to histopathological and clinical properties. Our study included a total of 236 patients, of whom 119 had colorectal cancer (42 women, 77 men) and 117 were healthy controls. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and allele-specific oligonucleotide (ASO) PCR methods were used. In addition, the serum galectin-3 level was studied with the enzyme-linked immunosorbent assay (ELISA) method. For the rs4644 variant of the LGALS3 gene, the CC genotype a mucinous component was significantly more common than those without a mucinous component (p=0.026). C allele frequency of the rs214250 variant of the AXIN1 gene was significantly correlated to tumor size in the advanced tumor stage (p=0.022). The CCAACT haplotype was more common in colorectal cancer patients (p=0.022). Serum galectin-3 level was higher in the patient group compared to the control group (5.9± 0.69 ng/ml vs. 0.79±0.01 ng/ml; p<0.001). In conclusion, variants of LGALS3 and AXIN1 genes affect tumor sizes and the mucinous component via Wnt/?-catenin pathway in the pathogenesis of colorectal cancer. äLGALS3 and AXIN1 gene variants playing role in the Wnt/?-catenin signa(epmc).pdf DeepDyve Pubget Overpricing