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10.1101/cshperspect.a026070 http://scihub22266oqcxt.onion/10.1101/cshperspect.a026070 C4852800!4852800!27048304     free     free     free       Cold+Spring+Harb+Perspect+Med 2016 ; 6 (5): ä Nephropedia Template TP {{tp|p=27048304|t=2016. p53 in the DNA-Damage-Repair Process |pdf=|usr=}}{{27048304}} gab.com Text p53 in the DNA-Damage-Repair Process JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=27048304 #FOAvip The cells in the human body are continuously challenged by a variety of genotoxic attacks. Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can alter the functions of tumor suppressor genes or oncogenes, thus causing cancer development. As a central tumor suppressor, p53 guards the genome by orchestrating a variety of DNA-damage-response (DDR) mechanisms. Already early in metazoan evolution, p53 started controlling the apoptotic demise of genomically compromised cells. p53 plays a prominent role as a facilitator of DNA repair by halting the cell cycle to allow time for the repair machineries to restore genome stability. In addition, p53 took on diverse roles to also directly impact the activity of various DNA-repair systems. It thus appears as if p53 is multitasking in providing protection from cancer development by maintaining genome stability. Twit Text FOAVip p53 in the DNA-Damage-Repair Process ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=27048304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27048304 #FOAvip English Wikipedia <ref>{{Cite pmid|27048304}}</ref> p53 in the DNA-Damage-Repair Process #MMPMID27048304 Williams AB; Schumacher B Cold Spring Harb Perspect Med 2016[May]; 6 (5): ä PMID27048304show ga The cells in the human body are continuously challenged by a variety of genotoxic attacks. Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can alter the functions of tumor suppressor genes or oncogenes, thus causing cancer development. As a central tumor suppressor, p53 guards the genome by orchestrating a variety of DNA-damage-response (DDR) mechanisms. Already early in metazoan evolution, p53 started controlling the apoptotic demise of genomically compromised cells. p53 plays a prominent role as a facilitator of DNA repair by halting the cell cycle to allow time for the repair machineries to restore genome stability. In addition, p53 took on diverse roles to also directly impact the activity of various DNA-repair systems. It thus appears as if p53 is multitasking in providing protection from cancer development by maintaining genome stability. äp53 in the DNA-Damage-Repair Process (epmc).pdf DeepDyve Pubget Overpricing