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10.1101/cshperspect.a022780 http://scihub22266oqcxt.onion/10.1101/cshperspect.a022780 C4852797!4852797!26801895     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Med 2016 ; 6 (5): ä Nephropedia Template TP {{tp|p=26801895|t=2016. Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet |pdf=|usr=}}{{26801895}} gab.com Text Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=26801895 #FOAvip Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic treatment for people with epilepsy, but not all patients become free of seizures. The ketogenic diet is one treatment option for drug-resistant patients. Both types of therapy exert their clinical effects through interactions with one or more of a diverse set of molecular targets in the brain. ASDs act by modulation of voltage-gated ion channels, including sodium, calcium, and potassium channels; by enhancement of ?-aminobutyric acid (GABA)-mediated inhibition through effects on GABAA receptors, the GABA transporter 1 (GAT1) GABA uptake transporter, or GABA transaminase; through interactions with elements of the synaptic release machinery, including synaptic vesicle 2A (SV2A) and ?2?; or by blockade of ionotropic glutamate receptors, including ?-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors. The ketogenic diet leads to increases in circulating ketones, which may contribute to the efficacy in treating pharmacoresistant seizures. Production in the brain of inhibitory mediators, such as adenosine, or ion channel modulators, such as polyunsaturated fatty acids, may also play a role. Metabolic effects, including diversion from glycolysis, are a further postulated mechanism. For some ASDs and the ketogenic diet, effects on multiple targets may contribute to activity. Better understanding of the ketogenic diet will inform the development of improved drug therapies to treat refractory seizures. Twit Text FOAVip Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=26801895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26801895 #FOAvip English Wikipedia <ref>{{Cite pmid|26801895}}</ref> Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet #MMPMID26801895 Rogawski MA; Löscher W; Rho JM Cold Spring Harb Perspect Med 2016[May]; 6 (5): ä PMID26801895show ga Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic treatment for people with epilepsy, but not all patients become free of seizures. The ketogenic diet is one treatment option for drug-resistant patients. Both types of therapy exert their clinical effects through interactions with one or more of a diverse set of molecular targets in the brain. ASDs act by modulation of voltage-gated ion channels, including sodium, calcium, and potassium channels; by enhancement of ?-aminobutyric acid (GABA)-mediated inhibition through effects on GABAA receptors, the GABA transporter 1 (GAT1) GABA uptake transporter, or GABA transaminase; through interactions with elements of the synaptic release machinery, including synaptic vesicle 2A (SV2A) and ?2?; or by blockade of ionotropic glutamate receptors, including ?-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors. The ketogenic diet leads to increases in circulating ketones, which may contribute to the efficacy in treating pharmacoresistant seizures. Production in the brain of inhibitory mediators, such as adenosine, or ion channel modulators, such as polyunsaturated fatty acids, may also play a role. Metabolic effects, including diversion from glycolysis, are a further postulated mechanism. For some ASDs and the ketogenic diet, effects on multiple targets may contribute to activity. Better understanding of the ketogenic diet will inform the development of improved drug therapies to treat refractory seizures. äMechanisms of Action of Antiseizure Drugs and the Ketogenic Diet (epmc).pdf DeepDyve Pubget Overpricing