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10.1101/cshperspect.a025924 http://scihub22266oqcxt.onion/10.1101/cshperspect.a025924 C4852795!4852795!27048303     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Med 2016 ; 6 (5): ä Nephropedia Template TP {{tp|p=27048303|t=2016. Inhibition of the Mechanistic Target of Rapamycin (mTOR)?Rapamycin and Beyond |pdf=|usr=}}{{27048303}} gab.com Text Inhibition of the Mechanistic Target of Rapamycin (mTOR) Rapamycin and Beyond JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=27048303 #FOAvip Rapamycin is a Food and Drug Administration (FDA)-approved immunosuppressant and anticancer agent discovered in the soil of Easter Island in the early 1970s. Rapamycin is a potent and selective inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, which acts as a central integrator of nutrient signaling pathways. During the last decade, genetic and pharmaceutical inhibition of mTOR pathway signaling has been found to promote longevity in yeast, worms, flies, and mice. In this article, we will discuss the molecular biology underlying the effects of rapamycin and its physiological effects, evidence for rapamycin as an antiaging compound, mechanisms by which rapamycin may extend life span, and the potential limitations of rapamycin as an antiaging molecule. Finally, we will discuss possible strategies that may allow us to inhibit mTOR signaling safely while minimizing side effects, and reap the health, social, and economic benefits from slowing the aging process. Twit Text FOAVip Inhibition of the Mechanistic Target of Rapamycin (mTOR) Rapamycin and Beyond ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=27048303 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27048303 #FOAvip English Wikipedia <ref>{{Cite pmid|27048303}}</ref> Inhibition of the Mechanistic Target of Rapamycin (mTOR)?Rapamycin and Beyond #MMPMID27048303 Lamming DW Cold Spring Harb Perspect Med 2016[May]; 6 (5): ä PMID27048303show ga Rapamycin is a Food and Drug Administration (FDA)-approved immunosuppressant and anticancer agent discovered in the soil of Easter Island in the early 1970s. Rapamycin is a potent and selective inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, which acts as a central integrator of nutrient signaling pathways. During the last decade, genetic and pharmaceutical inhibition of mTOR pathway signaling has been found to promote longevity in yeast, worms, flies, and mice. In this article, we will discuss the molecular biology underlying the effects of rapamycin and its physiological effects, evidence for rapamycin as an antiaging compound, mechanisms by which rapamycin may extend life span, and the potential limitations of rapamycin as an antiaging molecule. Finally, we will discuss possible strategies that may allow us to inhibit mTOR signaling safely while minimizing side effects, and reap the health, social, and economic benefits from slowing the aging process. äInhibition of the Mechanistic Target of Rapamycin (mTOR)?Rapamycin and(epmc).pdf DeepDyve Pubget Overpricing