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10.1038/nrm3679

http://scihub22266oqcxt.onion/10.1038/nrm3679
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C4852478!4852478!24105322
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suck abstract from ncbi


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pmid24105322      Nat+Rev+Mol+Cell+Biol 2013 ; 14 (11): 699-712
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  • RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts #MMPMID24105322
  • Geisler S; Coller J
  • Nat Rev Mol Cell Biol 2013[Nov]; 14 (11): 699-712 PMID24105322show ga
  • The increased application of transcriptome-wide profiling approaches has led to an explosion in the number of documented long non-coding RNAs (lncRNAs). While these new and enigmatic players in the complex transcriptional milieu are encoded by a significant proportion of the genome, their functions are mostly unknown. Early discoveries support a paradigm in which lncRNAs regulate transcription via chromatin modulation, but new functions are steadily emerging. Given the biochemical versatility of RNA, lncRNAs may be used for various tasks, including post-transcriptional regulation, organization of protein complexes, cell-cell signalling and allosteric regulation of proteins.
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