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10.1016/j.bbamcr.2015.11.016 http://scihub22266oqcxt.onion/10.1016/j.bbamcr.2015.11.016 C4851888!4851888!26608610     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2016 ; 1863 (6 Pt B): 1344-50 Nephropedia Template TP {{tp|p=26608610|t=2016. Calcium-ATPases: Gene Disorders and Dysregulation in Cancer |pdf=|usr=}}{{26608610}} gab.com Text Calcium-ATPases: Gene Disorders and Dysregulation in Cancer JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=26608610 #FOAvip Ca2+-ATPases belonging to the superfamily of P-type pumps play an important role in maintaining low, nanomolar cytoplasmic Ca2+ levels at rest and priming organellar stores, including the endoplasmic reticulum, Golgi and secretory vesicles with high levels of Ca2+ for a wide range of signaling functions. In this review, we introduce the distinct subtypes of Ca2+-ATPases and their isoforms and splice variants, and provide an overview of their specific cellular roles as they relate to genetic disorders and cancer, with a particular emphasis on recent findings on the secretory pathway Ca2+-ATPases (SPCA). Mutations in human ATP2A2, ATP2C1 genes, encoding housekeeping isoforms of the endoplasmic reticulum (SERCA2) and secretory pathway (SPCA1) pumps respectively, confer autosomal dominant disorders of the skin, whereas mutations in other isoforms underlie various muscular, neurological or developmental disorders. Emerging evidence points to an important function of dysregulated Ca2+-ATPase expression in cancers of the breast, colon, lung and breast where they may serve as markers of differentiation or novel targets for therapeutic intervention. We review the mechanisms underlying the link between calcium homeostasis and cancer and discuss the potential clinical relevance of these observations. Twit Text FOAVip Calcium-ATPases: Gene Disorders and Dysregulation in Cancer ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=26608610 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26608610 #FOAvip English Wikipedia <ref>{{Cite pmid|26608610}}</ref> Calcium-ATPases: Gene Disorders and Dysregulation in Cancer #MMPMID26608610 Dang D; Rao R Biochim Biophys Acta 2016[Jun]; 1863 (6 Pt B): 1344-50 PMID26608610show ga Ca2+-ATPases belonging to the superfamily of P-type pumps play an important role in maintaining low, nanomolar cytoplasmic Ca2+ levels at rest and priming organellar stores, including the endoplasmic reticulum, Golgi and secretory vesicles with high levels of Ca2+ for a wide range of signaling functions. In this review, we introduce the distinct subtypes of Ca2+-ATPases and their isoforms and splice variants, and provide an overview of their specific cellular roles as they relate to genetic disorders and cancer, with a particular emphasis on recent findings on the secretory pathway Ca2+-ATPases (SPCA). Mutations in human ATP2A2, ATP2C1 genes, encoding housekeeping isoforms of the endoplasmic reticulum (SERCA2) and secretory pathway (SPCA1) pumps respectively, confer autosomal dominant disorders of the skin, whereas mutations in other isoforms underlie various muscular, neurological or developmental disorders. Emerging evidence points to an important function of dysregulated Ca2+-ATPase expression in cancers of the breast, colon, lung and breast where they may serve as markers of differentiation or novel targets for therapeutic intervention. We review the mechanisms underlying the link between calcium homeostasis and cancer and discuss the potential clinical relevance of these observations. äCalcium-ATPases: Gene Disorders and Dysregulation in Cancer (epmc).pdf DeepDyve Pubget Overpricing