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"TRP inflammation" relationship in cardiovascular system
#MMPMID26482920
Numata T
; Takahashi K
; Inoue R
Semin Immunopathol
2016[May]; 38
(3
): 339-56
PMID26482920
show ga
Despite considerable advances in the research and treatment, the precise
relationship between inflammation and cardiovascular (CV) disease remains
incompletely understood. Therefore, understanding the immunoinflammatory
processes underlying the initiation, progression, and exacerbation of many
cardiovascular diseases is of prime importance. The innate immune system has an
ancient origin and is well conserved across species. Its activation occurs in
response to pathogens or tissue injury. Recent studies suggest that altered ionic
balance, and production of noxious gaseous mediators link to immune and
inflammatory responses with altered ion channel expression and function. Among
plausible candidates for this are transient receptor potential (TRP) channels
that function as polymodal sensors and scaffolding proteins involved in many
physiological and pathological processes. In this review, we will first focus on
the relevance of TRP channel to both exogenous and endogenous factors related to
innate immune response and transcription factors related to sustained
inflammatory status. The emerging role of inflammasome to regulate innate
immunity and its possible connection to TRP channels will also be discussed.
Secondly, we will discuss about the linkage of TRP channels to inflammatory CV
diseases, from a viewpoint of inflammation in a general sense which is not
restricted to the innate immunity. These knowledge may serve to provide new
insights into the pathogenesis of various inflammatory CV diseases and their
novel therapeutic strategies.
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