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10.1016/j.yexcr.2015.10.033 http://scihub22266oqcxt.onion/10.1016/j.yexcr.2015.10.033 C4851608!4851608!26524505     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Cell+Res 2016 ; 343 (1): 60-6 Nephropedia Template TP {{tp|p=26524505|t=2016. Mechanosensing via cell-matrix adhesions in 3D microenvironments |pdf=|usr=}}{{26524505}} gab.com Text Mechanosensing via cell-matrix adhesions in 3D microenvironments JO: Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=26524505 #FOAvip The extracellular matrix (ECM) microenvironment plays a central role in cell migration by providing physiochemical information that influences overall cell behavior. Much of this external information is accessed by direct interaction of the cell with ECM ligands and structures via integrin-based adhesions that are hypothesized to act as mechanosensors for testing the surrounding microenvironment. Our current understanding of these mechanical complexes is derived primarily from studies of cellular adhesions formed on two-dimensional (2D) substrates in vitro. Yet the rules of cell/ECM engagement and mechanosensing in three-dimensional (3D) microenvironments are invariably more complex under both in vitro and in vivo conditions. Here we review the current understanding of how cellular mechanosensing occurs through adhesion complexes within 3D microenvironments and discuss how these mechanisms can vary and differ from interactions on 2D substrates. Twit Text FOAVip Mechanosensing via cell-matrix adhesions in 3D microenvironments ????Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=26524505 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26524505 #FOAvip English Wikipedia <ref>{{Cite pmid|26524505}}</ref> Mechanosensing via cell-matrix adhesions in 3D microenvironments #MMPMID26524505 Doyle AD; Yamada KM Exp Cell Res 2016[Apr]; 343 (1): 60-6 PMID26524505show ga The extracellular matrix (ECM) microenvironment plays a central role in cell migration by providing physiochemical information that influences overall cell behavior. Much of this external information is accessed by direct interaction of the cell with ECM ligands and structures via integrin-based adhesions that are hypothesized to act as mechanosensors for testing the surrounding microenvironment. Our current understanding of these mechanical complexes is derived primarily from studies of cellular adhesions formed on two-dimensional (2D) substrates in vitro. Yet the rules of cell/ECM engagement and mechanosensing in three-dimensional (3D) microenvironments are invariably more complex under both in vitro and in vivo conditions. Here we review the current understanding of how cellular mechanosensing occurs through adhesion complexes within 3D microenvironments and discuss how these mechanisms can vary and differ from interactions on 2D substrates. äMechanosensing via cell-matrix adhesions in 3D microenvironments (epmc).pdf DeepDyve Pubget Overpricing