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10.1016/j.yexcr.2015.10.038 http://scihub22266oqcxt.onion/10.1016/j.yexcr.2015.10.038 C4851576!4851576!26546985     free     free     free       Exp+Cell+Res 2016 ; 343 (1): 89-95 Nephropedia Template TP {{tp|p=26546985|t=2016. Regulation of invadopodia by mechanical signaling |pdf=|usr=}}{{26546985}} gab.com Text Regulation of invadopodia by mechanical signaling JO: Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=26546985 #FOAvip Mechanical rigidity in the tumor microenvironment is associated with a high risk of tumor formation and aggressiveness. Adhesion-based signaling driven by a rigid microenvironment is thought to facilitate invasion and migration of cancer cells away from primary tumors. Proteolytic degradation of extracellular matrix (ECM) is a key component of this process and is mediated by subcellular actin-rich structures known as invadopodia. Both ECM rigidity and cellular traction stresses promote invadopodia formation and activity, suggesting a role for these structures in mechanosensing. The presence and activity of mechanosensitive adhesive and signaling components at invadopodia further indicates the potential for these structures to utilize myosin-dependent forces to probe and remodel their ECM environments. Here, we provide a brief review of the role of adhesion-based mechanical signaling in controlling invadopodia and invasive cancer behavior. Twit Text FOAVip Regulation of invadopodia by mechanical signaling ????Exp Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=26546985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26546985 #FOAvip English Wikipedia <ref>{{Cite pmid|26546985}}</ref> Regulation of invadopodia by mechanical signaling #MMPMID26546985 Parekh A; Weaver AM Exp Cell Res 2016[Apr]; 343 (1): 89-95 PMID26546985show ga Mechanical rigidity in the tumor microenvironment is associated with a high risk of tumor formation and aggressiveness. Adhesion-based signaling driven by a rigid microenvironment is thought to facilitate invasion and migration of cancer cells away from primary tumors. Proteolytic degradation of extracellular matrix (ECM) is a key component of this process and is mediated by subcellular actin-rich structures known as invadopodia. Both ECM rigidity and cellular traction stresses promote invadopodia formation and activity, suggesting a role for these structures in mechanosensing. The presence and activity of mechanosensitive adhesive and signaling components at invadopodia further indicates the potential for these structures to utilize myosin-dependent forces to probe and remodel their ECM environments. Here, we provide a brief review of the role of adhesion-based mechanical signaling in controlling invadopodia and invasive cancer behavior. äRegulation of invadopodia by mechanical signaling (epmc).pdf DeepDyve Pubget Overpricing