Inhibition of autophagy with clarithromycin: a new strategy to enhance
sensitivity of CML stem cells to tyrosine kinase inhibitors
#MMPMID27175249
Carella AM
; Beltrami G
; Catania G
; Pica G
; Ghiggi C
; Garuti A
; Carella A
Leuk Suppl
2012[Aug]; 1
(Suppl 2
): S49-50
PMID27175249
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Autophagy inhibition has been shown to sensitize tumor cells to cell death
induced by tyrosine kinase inhibitors (TKIs). The remarkable responses obtained
in seven patients with the combination of clarithromycin and TKIs support the
hypothesis that the inhibition of autophagy may make chronic myeloid leukemia
cells sensitive to killing by TKIs.