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Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of
Highly Active Gene Promoters
#MMPMID27105113
Goudarzi A
; Zhang D
; Huang H
; Barral S
; Kwon OK
; Qi S
; Tang Z
; Buchou T
; Vitte AL
; He T
; Cheng Z
; Montellier E
; Gaucher J
; Curtet S
; Debernardi A
; Charbonnier G
; Puthier D
; Petosa C
; Panne D
; Rousseaux S
; Roeder RG
; Zhao Y
; Khochbin S
Mol Cell
2016[Apr]; 62
(2
): 169-180
PMID27105113
show ga
Recently discovered histone lysine acylation marks increase the functional
diversity of nucleosomes well beyond acetylation. Here, we focus on histone
butyrylation in the context of sperm cell differentiation. Specifically, we
investigate the butyrylation of histone H4 lysine 5 and 8 at gene promoters where
acetylation guides the binding of Brdt, a bromodomain-containing protein, thereby
mediating stage-specific gene expression programs and post-meiotic chromatin
reorganization. Genome-wide mapping data show that highly active Brdt-bound gene
promoters systematically harbor competing histone acetylation and butyrylation
marks at H4 K5 and H4 K8. Despite acting as a direct stimulator of transcription,
histone butyrylation competes with acetylation, especially at H4 K5, to prevent
Brdt binding. Additionally, H4 K5K8 butyrylation also marks retarded histone
removal during late spermatogenesis. Hence, alternating H4 acetylation and
butyrylation, while sustaining direct gene activation and dynamic bromodomain
binding, could impact the final male epigenome features.
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