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10.1016/j.celrep.2016.03.041 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.03.041 C4850359!4850359!27068460     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (3): 638-50 Nephropedia Template TP {{tp|p=27068460|t=2016. Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis |pdf=|usr=}}{{27068460}} gab.com Text Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27068460 #FOAvip The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that lithium extends lifespan in female and male Drosophila, when administered throughout adulthood or only later in life. The life-extending mechanism involves the inhibition of glycogen synthase kinase-3 (GSK-3) and activation of the transcription factor nuclear factor erythroid 2-related factor (NRF-2). Combining genetic loss of the NRF-2 repressor Kelch-like ECH-associated protein 1 (Keap1) with lithium treatment revealed that high levels of NRF-2 activation conferred stress resistance, while low levels additionally promoted longevity. The discovery of GSK-3 as a therapeutic target for aging will likely lead to more effective treatments that can modulate mammalian aging and further improve health in later life. Twit Text FOAVip Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27068460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27068460 #FOAvip English Wikipedia <ref>{{Cite pmid|27068460}}</ref> Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis #MMPMID27068460 Castillo-Quan J; Li L; Kinghorn K; Ivanov D; Tain L; Slack C; Kerr F; Nespital T; Thornton J; Hardy J; Bjedov I; Partridge L Cell Rep 2016[Apr]; 15 (3): 638-50 PMID27068460show ga The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that lithium extends lifespan in female and male Drosophila, when administered throughout adulthood or only later in life. The life-extending mechanism involves the inhibition of glycogen synthase kinase-3 (GSK-3) and activation of the transcription factor nuclear factor erythroid 2-related factor (NRF-2). Combining genetic loss of the NRF-2 repressor Kelch-like ECH-associated protein 1 (Keap1) with lithium treatment revealed that high levels of NRF-2 activation conferred stress resistance, while low levels additionally promoted longevity. The discovery of GSK-3 as a therapeutic target for aging will likely lead to more effective treatments that can modulate mammalian aging and further improve health in later life. äLithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis (epmc).pdf DeepDyve Pubget Overpricing