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10.1080/19336950.2015.1089007 http://scihub22266oqcxt.onion/10.1080/19336950.2015.1089007 C4850047!4850047 !26569161     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26569161 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Channels+(Austin) 2015 ; 9 (6 ): 380-96 Nephropedia Template TP {{tp|p=26569161 |t=2015. Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance |pdf=|usr=}}{{26569161 }} gab.com Text Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance JO: Channels (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=26569161 #FOAvip Volume-regulated channels for anions (VRAC) / organic osmolytes (VSOAC) play essential roles in cell volume regulation and other cellular functions, e.g. proliferation, cell migration and apoptosis. LRRC8A, which belongs to the leucine rich-repeat containing protein family, was recently shown to be an essential component of both VRAC and VSOAC. Reduced VRAC and VSOAC activities are seen in drug resistant cancer cells. ANO1 is a calcium-activated chloride channel expressed on the plasma membrane of e.g., secretory epithelia. ANO1 is amplified and highly expressed in a large number of carcinomas. The gene, encoding for ANO1, maps to a region on chromosome 11 (11q13) that is frequently amplified in cancer cells. Knockdown of ANO1 impairs cell proliferation and cell migration in several cancer cells. Below we summarize the basic biophysical properties of VRAC, VSOAC and ANO1 and their most important cellular functions as well as their role in cancer and drug resistance. Twit Text FOAVip Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance ????Channels (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=26569161 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26569161 #FOAvip English Wikipedia <ref>{{Cite pmid|26569161 }}</ref> Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance #MMPMID26569161 Hoffmann EK ; Sørensen BH ; Sauter DP ; Lambert IH Channels (Austin) 2015[]; 9 (6 ): 380-96 PMID26569161 show ga Volume-regulated channels for anions (VRAC) / organic osmolytes (VSOAC) play essential roles in cell volume regulation and other cellular functions, e.g. proliferation, cell migration and apoptosis. LRRC8A, which belongs to the leucine rich-repeat containing protein family, was recently shown to be an essential component of both VRAC and VSOAC. Reduced VRAC and VSOAC activities are seen in drug resistant cancer cells. ANO1 is a calcium-activated chloride channel expressed on the plasma membrane of e.g., secretory epithelia. ANO1 is amplified and highly expressed in a large number of carcinomas. The gene, encoding for ANO1, maps to a region on chromosome 11 (11q13) that is frequently amplified in cancer cells. Knockdown of ANO1 impairs cell proliferation and cell migration in several cancer cells. Below we summarize the basic biophysical properties of VRAC, VSOAC and ANO1 and their most important cellular functions as well as their role in cancer and drug resistance. |*Cell Size [MESH] |*Drug Resistance, Neoplasm [MESH] |Animals [MESH] |Anoctamin-1 [MESH] |Apoptosis [MESH] |Chloride Channels/genetics/*metabolism [MESH] |Homeostasis [MESH] |Humans [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Neoplasm Proteins/genetics/*metabolism [MESH]Role of volume-regulated and calcium-activated anion channels in cell (epmc).pdf DeepDyve Pubget Overpricing