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Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic
Classification, Diagnosis, and Reporting of GN
#MMPMID26567243
Sethi S
; Haas M
; Markowitz GS
; D'Agati VD
; Rennke HG
; Jennette JC
; Bajema IM
; Alpers CE
; Chang A
; Cornell LD
; Cosio FG
; Fogo AB
; Glassock RJ
; Hariharan S
; Kambham N
; Lager DJ
; Leung N
; Mengel M
; Nath KA
; Roberts IS
; Rovin BH
; Seshan SV
; Smith RJ
; Walker PD
; Winearls CG
; Appel GB
; Alexander MP
; Cattran DC
; Casado CA
; Cook HT
; De Vriese AS
; Radhakrishnan J
; Racusen LC
; Ronco P
; Fervenza FC
J Am Soc Nephrol
2016[May]; 27
(5
): 1278-87
PMID26567243
show ga
Renal pathologists and nephrologists met on February 20, 2015 to establish an
etiology/pathogenesis-based system for classification and diagnosis of GN, with a
major aim of standardizing the kidney biopsy report of GN. On the basis of
etiology/pathogenesis, GN is classified into the following five pathogenic types,
each with specific disease entities: immune-complex GN, pauci-immune GN,
antiglomerular basement membrane GN, monoclonal Ig GN, and C3 glomerulopathy. The
pathogenesis-based classification forms the basis of the kidney biopsy report. To
standardize the report, the diagnosis consists of a primary diagnosis and a
secondary diagnosis. The primary diagnosis should include the disease
entity/pathogenic type (if disease entity is not known) followed in order by
pattern of injury (mixed patterns may be present); score/grade/class for disease
entities, such as IgA nephropathy, lupus nephritis, and ANCA GN; and additional
features as detailed herein. A pattern diagnosis as the sole primary diagnosis is
not recommended. Secondary diagnoses should be reported separately and include
coexisting lesions that do not form the primary diagnosis. Guidelines for the
report format, light microscopy, immunofluorescence microscopy, electron
microscopy, and ancillary studies are also provided. In summary, this consensus
report emphasizes a pathogenesis-based classification of GN and provides
guidelines for the standardized reporting of GN.
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