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2016 ; 10
(3
): 356-61
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The Effects of Helicobacter pylori Eradication Therapy for Chronic
IdiopathicThrombocytopenic Purpura
#MMPMID26347517
Hwang JJ
; Lee DH
; Yoon H
; Shin CM
; Park YS
; Kim N
Gut Liver
2016[May]; 10
(3
): 356-61
PMID26347517
show ga
BACKGROUND/AIMS: The aim of this study was to evaluate the ability of
Helicobacter pylori eradication treatment to increase platelet counts in Korean
patients with chronic idiopathic thrombocytopenic purpura (ITP). METHODS: A total
of 102 patients were evaluated against two criteria. First, those diagnosed with
H. pylori infections in whom eradication was successful were assigned to the H.
pylori-positive and -eradicated group (n=39), whereas those diagnosed with H.
pylori infections in whom eradication failed were assigned to the H.
pylori-positive and -non-eradicated group (n=3), and those without H. pylori
infections were assigned to the H. pylori - negative group (n=60). Second,
patients with complete remission in whom the platelet recovery effect was
maintained over the average follow-up period of 6 months after eradication
therapy were defined as the responder group (n=58), whereas those with partial or
no response were defined as the nonresponder group (n=44). RESULTS: The platelet
counts of the H. pylori-positive and -eradicated group were significantly
increased 6 months after eradication therapy compared to those of the H.
pylori-positive and -non-eradicated group and the H. pylori-negative group
(43.2±29.1 to 155.3±68.7×10³/?L vs 42.5±28.1 to 79.8±59.7×10³/?L vs 43.1±28.9 to
81.2±62.2×10³/?L; p=0.041). The eradication therapy success rate in the responder
group was 100.0% (39/39), in contrast to the nonresponder group (0%, 0/3)
(p<0.001). CONCLUSIONS: H. pylori eradication therapy was related to increased
platelet count, and successful eradication affected the increased platelet count
in Korean patients with chronic ITP.
|*Disease Eradication
[MESH]
|*Helicobacter pylori
[MESH]
|Antiviral Agents/therapeutic use
[MESH]
|Chronic Disease
[MESH]
|Female
[MESH]
|Helicobacter Infections/ethnology/*prevention & control
[MESH]