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10.1164/rccm.201502-0407OC http://scihub22266oqcxt.onion/10.1164/rccm.201502-0407OC C4849178!4849178!26651104     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Crit+Care+Med 2016 ; 193 (8): 898-909 Nephropedia Template TP {{tp|p=26651104|t=2016. Bone Marrow?derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension |pdf=|usr=}}{{26651104}} gab.com Text Bone Marrow derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=26651104 #FOAvip Rationale: Pulmonary arterial hypertension (PAH) is a progressive lung disease of the pulmonary microvasculature. Studies suggest that bone marrow (BM)-derived circulating cells may play an important role in its pathogenesis.Objectives: We used a genetic model of PAH, the Bmpr2 mutant mouse, to study the role of BM-derived circulating cells in its pathogenesis.Methods: Recipient mice, either Bmpr2R899X mutant or controls, were lethally irradiated and transplanted with either control or Bmpr2R899X BM cells. Donor cells were traced in female recipient mice by Y chromosome painting. Molecular and function insights were provided by expression and cytokine arrays combined with flow cytometry, colony-forming assays, and competitive transplant assays.Measurements and Main Results: We found that mutant BM cells caused PAH with remodeling and inflammation when transplanted into control mice, whereas control BM cells had a protective effect against the development of disease, when transplanted into mutant mice. Donor BM-derived cells were present in the lungs of recipient mice. Functional and molecular analysis identified mutant BM cell dysfunction suggestive of a PAH phenotype soon after activation of the transgene and long before the development of lung pathology.Conclusions: Our data show that BM cells played a key role in PAH pathogenesis and that the transplanted BM cells were able to drive the lung phenotype in a myeloablative transplant model. Furthermore, the specific cell types involved were derived from hematopoietic stem cells and exhibit dysfunction long before the development of lung pathology. Twit Text FOAVip Bone Marrow derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=26651104 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26651104 #FOAvip English Wikipedia <ref>{{Cite pmid|26651104}}</ref> Bone Marrow?derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension #MMPMID26651104 Yan L; Chen X; Talati M; Nunley BW; Gladson S; Blackwell T; Cogan J; Austin E; Wheeler F; Loyd J; West J; Hamid R Am J Respir Crit Care Med 2016[Apr]; 193 (8): 898-909 PMID26651104show ga Rationale: Pulmonary arterial hypertension (PAH) is a progressive lung disease of the pulmonary microvasculature. Studies suggest that bone marrow (BM)-derived circulating cells may play an important role in its pathogenesis.Objectives: We used a genetic model of PAH, the Bmpr2 mutant mouse, to study the role of BM-derived circulating cells in its pathogenesis.Methods: Recipient mice, either Bmpr2R899X mutant or controls, were lethally irradiated and transplanted with either control or Bmpr2R899X BM cells. Donor cells were traced in female recipient mice by Y chromosome painting. Molecular and function insights were provided by expression and cytokine arrays combined with flow cytometry, colony-forming assays, and competitive transplant assays.Measurements and Main Results: We found that mutant BM cells caused PAH with remodeling and inflammation when transplanted into control mice, whereas control BM cells had a protective effect against the development of disease, when transplanted into mutant mice. Donor BM-derived cells were present in the lungs of recipient mice. Functional and molecular analysis identified mutant BM cell dysfunction suggestive of a PAH phenotype soon after activation of the transgene and long before the development of lung pathology.Conclusions: Our data show that BM cells played a key role in PAH pathogenesis and that the transplanted BM cells were able to drive the lung phenotype in a myeloablative transplant model. Furthermore, the specific cell types involved were derived from hematopoietic stem cells and exhibit dysfunction long before the development of lung pathology. äBone Marrow?derived Cells Contribute to the Pathogenesis of Pulmonary (epmc).pdf DeepDyve Pubget Overpricing