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2016 ; 17
(4
): 562
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NAFLD and Chronic Kidney Disease
#MMPMID27089331
Marcuccilli M
; Chonchol M
Int J Mol Sci
2016[Apr]; 17
(4
): 562
PMID27089331
show ga
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic
liver disease in developed countries and it is now considered a risk factor for
cardiovascular disease. Evidence linking NAFLD to the development and progression
of chronic kidney disease (CKD) is emerging as a popular area of scientific
interest. The rise in simultaneous liver-kidney transplantation as well as the
significant cost associated with the presence of chronic kidney disease in the
NAFLD population make this entity a worthwhile target for screening and
therapeutic intervention. While several cross-sectional and case control studies
have been published to substantiate these theories, very little data exists on
the underlying cause of NAFLD and CKD. In this review, we will discuss the most
recent publications on the diagnosis of NAFLD as well new evidence regarding the
pathophysiology of NAFLD and CKD as an inflammatory disorder. These mechanisms
include the role of obesity, the renin-angiotensin system, and dysregulation of
fructose metabolism and lipogenesis in the development of both disorders. Further
investigation of these pathways may lead to novel therapies that aim to target
the NAFLD and CKD. However, more prospective studies that include information on
both renal and liver histology will be necessary in order to understand the
relationship between these diseases.
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