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10.1186/s40164-016-0041-6 http://scihub22266oqcxt.onion/10.1186/s40164-016-0041-6 C4848808!4848808 !27127725     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27127725 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Hematol+Oncol 2015 ; 5 (ä): 12 Nephropedia Template TP {{tp|p=27127725 |t=2015. A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes |pdf=|usr=}}{{27127725 }} gab.com Text A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes JO: Exp Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27127725 #FOAvip BACKGROUND: Dys-megakaryopoiesis is defined as ?10 % of dysplastic megakaryocytes in bone marrow smears by the World Health Organization. However, concordance rates for dysplastic megakaryocytes between different observers is low and, consequently, evaluation of dysmegakaryopoiesis is also often discordant. RESULTS: We performed CD41 immune staining and proposed a systematic classification of dys-megakaryopoiesis on bone marrow films: (1) micro-megakaryocytes (<12 µm); (2) micro-megakaryocytes (12-40 µm) with 1 nucleus; (3) micro-megakaryocytes (12-40 µm) with 2 nuclei; (4) micro-megakaryocytes (12-40 um) with multiple (more than 2) nuclei; (5) dysplastic megakaryocytes (?40 µm) with 1 nucleus; (6) dysplastic megakaryocytes (?40 µm) with 2 nuclei; and (7) dysplastic megakaryocytes (?40 µm) with multiple (more than 2) nuclei. Further, we evaluated the prognostic impact of micro-megakaryocytes and dysplastic mono-nucleated megakaryocytes on MDS patients. The best discriminator cut-off point for each group was determined by the minimal P value approach. In multivariate analyses micro-megakaryocytes ?25 % and dysplastic mono-nucleated megakaryocytes ?30 % were independent adverse prognostic factors (hazard ratio [HR] = 1.58 [95 % confidence interval [CI], 1.11, 2.23]; P = 0.010 and 1.53 [1.09, 2.16]; P = 0.014). CONCLUSIONS: Our data suggest integration of micro-megakaryocytes and dysplastic mono-nucleated megakaryocytes improve predictive accuracy of the international prognostic scoring system-revised (IPSS-R) scoring system. Twit Text FOAVip A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes ????Exp Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27127725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27127725 #FOAvip English Wikipedia <ref>{{Cite pmid|27127725 }}</ref> A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes #MMPMID27127725 Feng G ; Gale RP ; Cui W ; Cai W ; Huang G ; Xu Z ; Qin T ; Zhang Y ; Li B ; Fang L ; Zhang H ; Pan L ; Hu N ; Qu S ; Wang J ; Cui Y ; Xiao Z Exp Hematol Oncol 2015[]; 5 (ä): 12 PMID27127725 show ga BACKGROUND: Dys-megakaryopoiesis is defined as ?10 % of dysplastic megakaryocytes in bone marrow smears by the World Health Organization. However, concordance rates for dysplastic megakaryocytes between different observers is low and, consequently, evaluation of dysmegakaryopoiesis is also often discordant. RESULTS: We performed CD41 immune staining and proposed a systematic classification of dys-megakaryopoiesis on bone marrow films: (1) micro-megakaryocytes (<12 µm); (2) micro-megakaryocytes (12-40 µm) with 1 nucleus; (3) micro-megakaryocytes (12-40 µm) with 2 nuclei; (4) micro-megakaryocytes (12-40 um) with multiple (more than 2) nuclei; (5) dysplastic megakaryocytes (?40 µm) with 1 nucleus; (6) dysplastic megakaryocytes (?40 µm) with 2 nuclei; and (7) dysplastic megakaryocytes (?40 µm) with multiple (more than 2) nuclei. Further, we evaluated the prognostic impact of micro-megakaryocytes and dysplastic mono-nucleated megakaryocytes on MDS patients. The best discriminator cut-off point for each group was determined by the minimal P value approach. In multivariate analyses micro-megakaryocytes ?25 % and dysplastic mono-nucleated megakaryocytes ?30 % were independent adverse prognostic factors (hazard ratio [HR] = 1.58 [95 % confidence interval [CI], 1.11, 2.23]; P = 0.010 and 1.53 [1.09, 2.16]; P = 0.014). CONCLUSIONS: Our data suggest integration of micro-megakaryocytes and dysplastic mono-nucleated megakaryocytes improve predictive accuracy of the international prognostic scoring system-revised (IPSS-R) scoring system. äA systematic classification of megakaryocytic dysplasia and its impact(epmc).pdf DeepDyve Pubget Overpricing