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2016 ; 36 Suppl 1
(Suppl 1
): S1-S11
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When do newborns die? A systematic review of timing of overall and cause-specific
neonatal deaths in developing countries
#MMPMID27109087
Sankar MJ
; Natarajan CK
; Das RR
; Agarwal R
; Chandrasekaran A
; Paul VK
J Perinatol
2016[May]; 36 Suppl 1
(Suppl 1
): S1-S11
PMID27109087
show ga
About 99% of neonatal deaths occur in low- and middle-income countries. There is
a paucity of information on the exact timing of neonatal deaths in these
settings. The objective of this review was to determine the timing of overall and
cause-specific neonatal deaths in developing country settings. We searched
MEDLINE via PubMed, Cochrane CENTRAL, WHOLIS and CABI using sensitive search
strategies. Searches were limited to studies involving humans published in the
last 10 years. A total of 22 studies were included in the review. Pooled results
indicate that about 62% of the total neonatal deaths occurred during the first 3
days of life; the first day alone accounted for two-thirds. Almost all
asphyxia-related and the majority of prematurity- and malformation-related deaths
occurred in the first week of life (98%, 83% and 78%, respectively). Only
one-half of sepsis-related deaths occurred in the first week while one-quarter
occurred in each of the second and third to fourth weeks of life. The
distribution of both overall and cause-specific mortality did not differ greatly
between Asia and Africa. The first 3 days after birth account for about 30% of
under-five child deaths. The first week of life accounts for most of asphyxia-,
prematurity- and malformation-related mortality and one-half of sepsis-related
deaths.
|*Cause of Death
[MESH]
|*Perinatal Death
[MESH]
|*Time Factors
[MESH]
|Asphyxia Neonatorum/mortality
[MESH]
|Developing Countries/statistics & numerical data
[MESH]