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2016 ; 8
(4
): 88
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Use of Botulinum Toxin A in the Treatment of Lower Urinary Tract Disorders: A
Review of the Literature
#MMPMID27023601
Moore DC
; Cohn JA
; Dmochowski RR
Toxins (Basel)
2016[Mar]; 8
(4
): 88
PMID27023601
show ga
Botulinum neurotoxin (BoNT) is used to treat a variety of ailments, and its
therapeutic application in lower urinary tract disorders (LUTDs) is well studied.
Robust evidence supporting the efficacy and tolerability of BoNT in the treatment
of neurogenic detrusor overactivity (NDO) and non-neurogenic overactive bladder
(OAB) has led to regulatory approval for these conditions. Use of BoNT in the
treatment of interstitial cystitis/bladder pain syndrome, chronic pelvic pain,
and detrusor sphincter dyssynergia has demonstrated some promise, but is still
evolving and off-label for these indications. Trials to date do not support the
use of BoNT for benign prostatic hyperplasia. This comprehensive review outlines
the mechanisms of BoNT in the treatment of LUTDs in adults and presents
background and updated data examining the efficacy and adverse events associated
with the use of BoNT in common urologic applications.
|Botulinum Toxins, Type A/adverse effects/*therapeutic use
[MESH]