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10.1038/srep25108 http://scihub22266oqcxt.onion/10.1038/srep25108 C4848494!4848494!27121375     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27121375|t=2016. The orphan nuclear receptor NR4A2 is part of a p53?microRNA-34 network |pdf=|usr=}}{{27121375}} gab.com Text The orphan nuclear receptor NR4A2 is part of a p53 microRNA-34 network JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27121375 #FOAvip Nuclear receptor subfamily 4 group A member 2 (NR4A2) is an orphan nuclear receptor that is over-expressed in cancer and promotes cell proliferation, migration, transformation, and chemoresistance. Increased expression and function of NR4A2 have been attributed to various signaling pathways, but little is known about microRNA (miRNA) regulation of NR4A2 in cancer. To investigate the posttranscriptional regulation of NR4A2, we used a 3? untranslated region (UTR) reporter screen and identified miR-34 as a putative regulator of NR4A2. By using computer predictions, we identified and confirmed an miRNA recognition element in the 3? UTR of NR4A2 that was responsible for miR-34?mediated suppression. We next demonstrated that overexpression of exogenous miR-34 or activation of the p53 pathway, which regulates endogenous miR-34 expression, decreased NR4A2 expression. Consistent with previous reports, overexpression of NR4A2 blocked the induction of p53 target genes, including mir-34a. This was a phenotypic effect, as NR4A2 overexpression could rescue cells from p53-induced inhibition of proliferation. In summary, our results are the first characterization of a cancer-related miRNA capable of regulating NR4A2 and suggest a network and possible feedback mechanism involving p53, miR-34, and NR4A2. Twit Text FOAVip The orphan nuclear receptor NR4A2 is part of a p53 microRNA-34 network ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27121375 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27121375 #FOAvip English Wikipedia <ref>{{Cite pmid|27121375}}</ref> The orphan nuclear receptor NR4A2 is part of a p53?microRNA-34 network #MMPMID27121375 Beard JA; Tenga A; Hills J; Hoyer JD; Cherian MT; Wang YD; Chen T Sci Rep 2016[]; 6 (ä): ä PMID27121375show ga Nuclear receptor subfamily 4 group A member 2 (NR4A2) is an orphan nuclear receptor that is over-expressed in cancer and promotes cell proliferation, migration, transformation, and chemoresistance. Increased expression and function of NR4A2 have been attributed to various signaling pathways, but little is known about microRNA (miRNA) regulation of NR4A2 in cancer. To investigate the posttranscriptional regulation of NR4A2, we used a 3? untranslated region (UTR) reporter screen and identified miR-34 as a putative regulator of NR4A2. By using computer predictions, we identified and confirmed an miRNA recognition element in the 3? UTR of NR4A2 that was responsible for miR-34?mediated suppression. We next demonstrated that overexpression of exogenous miR-34 or activation of the p53 pathway, which regulates endogenous miR-34 expression, decreased NR4A2 expression. Consistent with previous reports, overexpression of NR4A2 blocked the induction of p53 target genes, including mir-34a. This was a phenotypic effect, as NR4A2 overexpression could rescue cells from p53-induced inhibition of proliferation. In summary, our results are the first characterization of a cancer-related miRNA capable of regulating NR4A2 and suggest a network and possible feedback mechanism involving p53, miR-34, and NR4A2. äThe orphan nuclear receptor NR4A2 is part of a p53?microRNA-34 network(epmc).pdf DeepDyve Pubget Overpricing