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10.1080/15384047.2015.1121346 http://scihub22266oqcxt.onion/10.1080/15384047.2015.1121346 C4848000!4848000 !26618552     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26618552 &cmd=llinks): Failed to open stream: HTTP request failed! 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Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2 |pdf=|usr=}}{{26618552 }} gab.com Text Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2 JO: Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26618552 #FOAvip Emerging evidence indicates that methylglyoxal (MG) can inhibit tumorigenesis. Glyoxalase I (GLOI), a MG degradation enzyme, is implicated in the progression of human malignancies. However, little is known about the roles of MG and GLOI in breast cancer. Our purpose was to investigate the anticancer effects of MG and inhibition of GLOI on breast cancer cells and the underlying mechanisms of these effects. Our findings demonstrate that cell viability, migration, invasion, colony formation, and tubule formation were significantly restrained by addition of MG or inhibition of GLOI, while apoptosis was significantly increased. Furthermore, the expression of p-JNK, p-ERK, and p-p38 was markedly upregulated by addition of MG or inhibition of GLOI, whereas MMP-9 and Bcl-2 expression levels were dramatically decreased. These effects were augmented by combined treatment with MG and inhibition of GLOI. Collectively, these data indicate that MG or inhibition of GLOI induces anticancer effects in breast cancer cells and that these effects are potentiated by combination of the 2. These effects were modulated by activation of the MAPK family and downregulation of Bcl-2 and MMP-9. These findings may provide a new approach for the treatment of breast cancer. Twit Text FOAVip Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2 ????Cancer Biol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26618552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26618552 #FOAvip English Wikipedia <ref>{{Cite pmid|26618552 }}</ref> Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2 #MMPMID26618552 Guo Y ; Zhang Y ; Yang X ; Lu P ; Yan X ; Xiao F ; Zhou H ; Wen C ; Shi M ; Lu J ; Meng QH Cancer Biol Ther 2016[]; 17 (2 ): 169-80 PMID26618552 show ga Emerging evidence indicates that methylglyoxal (MG) can inhibit tumorigenesis. Glyoxalase I (GLOI), a MG degradation enzyme, is implicated in the progression of human malignancies. However, little is known about the roles of MG and GLOI in breast cancer. Our purpose was to investigate the anticancer effects of MG and inhibition of GLOI on breast cancer cells and the underlying mechanisms of these effects. Our findings demonstrate that cell viability, migration, invasion, colony formation, and tubule formation were significantly restrained by addition of MG or inhibition of GLOI, while apoptosis was significantly increased. Furthermore, the expression of p-JNK, p-ERK, and p-p38 was markedly upregulated by addition of MG or inhibition of GLOI, whereas MMP-9 and Bcl-2 expression levels were dramatically decreased. These effects were augmented by combined treatment with MG and inhibition of GLOI. Collectively, these data indicate that MG or inhibition of GLOI induces anticancer effects in breast cancer cells and that these effects are potentiated by combination of the 2. These effects were modulated by activation of the MAPK family and downregulation of Bcl-2 and MMP-9. These findings may provide a new approach for the treatment of breast cancer. |Apoptosis/drug effects [MESH] |Breast Neoplasms/*drug therapy/genetics/pathology [MESH] |Carcinogenesis/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Humans [MESH] |Lactoylglutathione Lyase/antagonists & inhibitors/biosynthesis/*genetics [MESH] |MCF-7 Cells [MESH] |Matrix Metalloproteinase 9/*biosynthesis/genetics [MESH] |Mitogen-Activated Protein Kinase Kinases/genetics [MESH] |Neoplasm Invasiveness/genetics [MESH] |Proto-Oncogene Proteins c-bcl-2/*biosynthesis/genetics [MESH]Effects of methylglyoxal and glyoxalase I inhibition on breast cancer (epmc).pdf DeepDyve Pubget Overpricing