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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Diabetes+Investig
2016 ; 7
(3
): 286-96
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?-Cell regeneration through the transdifferentiation of pancreatic cells:
Pancreatic progenitor cells in the pancreas
#MMPMID27330712
Kim HS
; Lee MK
J Diabetes Investig
2016[May]; 7
(3
): 286-96
PMID27330712
show ga
Pancreatic progenitor cell research has been in the spotlight, as these cells
have the potential to replace pancreatic ?-cells for the treatment of type 1 and
2 diabetic patients with the absence or reduction of pancreatic ?-cells. During
the past few decades, the successful treatment of diabetes through
transplantation of the whole pancreas or isolated islets has nearly been
achieved. However, novel sources of pancreatic islets or insulin-producing cells
are required to provide sufficient amounts of donor tissues. To overcome this
limitation, the use of pancreatic progenitor cells is gaining more attention. In
particular, pancreatic exocrine cells, such as duct epithelial cells and acinar
cells, are attractive candidates for ?-cell regeneration because of their
differentiation potential and pancreatic lineage characteristics. It has been
assumed that ?-cell neogenesis from pancreatic progenitor cells could occur in
pancreatic ducts in the postnatal stage. Several studies have shown that
insulin-producing cells can arise in the duct tissue of the adult pancreas.
Acinar cells also might have the potential to differentiate into
insulin-producing cells. The present review summarizes recent progress in
research on the transdifferentiation of pancreatic exocrine cells into
insulin-producing cells, especially duct and acinar cells.