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http://scihub22266oqcxt.onion/ C4846923!4846923!27158366     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transl+Res 2016 ; 8 (2): 742-8 Nephropedia Template TP {{tp|p=27158366|t=2016. BRD7: a novel tumor suppressor gene in different cancers |pdf=|usr=}}{{27158366}} gab.com Text BRD7: a novel tumor suppressor gene in different cancers JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=27158366 #FOAvip BRD7 (bromodomain 7), also known as celtix-1, was first identified in nasopharyngeal carcinoma (NPC) cells in 2000. BRD7 is a crucial component of both functional p53 and BRCA1 (breast cancer 1, early onset) pathways. Recently, the BRD7 tumor suppressor status has been fully established. Previous studies demonstrated that BRD7 was downregulated in human breast cancer and the downregulation often associates with tumor progression. The expression of BRD7 was downregulated in various cancers, including breast cancer, NPC, gastric cancer, colorectal carcinoma, ovarian cancer, and prostate cancer. Moreover, BRD7 inhibited cancer cell growth and metastasis and promote apoptosis in vitro and in vivo via downregulating AKT pathway. In addition, BRD7 may regulate many signaling pathways including ras-raf-MEK-ERK and RB/E2F. In this review, we provide an overview of current knowledge concerning the role of BRD7 in tumor development and progression. To our knowledge, this is the first review about the role of this novel tumor suppressor gene BRD7in tumor development and progression. Twit Text FOAVip BRD7: a novel tumor suppressor gene in different cancers ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=27158366 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27158366 #FOAvip English Wikipedia <ref>{{Cite pmid|27158366}}</ref> BRD7: a novel tumor suppressor gene in different cancers #MMPMID27158366 Yu X; Li Z; Shen J Am J Transl Res 2016[]; 8 (2): 742-8 PMID27158366show ga BRD7 (bromodomain 7), also known as celtix-1, was first identified in nasopharyngeal carcinoma (NPC) cells in 2000. BRD7 is a crucial component of both functional p53 and BRCA1 (breast cancer 1, early onset) pathways. Recently, the BRD7 tumor suppressor status has been fully established. Previous studies demonstrated that BRD7 was downregulated in human breast cancer and the downregulation often associates with tumor progression. The expression of BRD7 was downregulated in various cancers, including breast cancer, NPC, gastric cancer, colorectal carcinoma, ovarian cancer, and prostate cancer. Moreover, BRD7 inhibited cancer cell growth and metastasis and promote apoptosis in vitro and in vivo via downregulating AKT pathway. In addition, BRD7 may regulate many signaling pathways including ras-raf-MEK-ERK and RB/E2F. In this review, we provide an overview of current knowledge concerning the role of BRD7 in tumor development and progression. To our knowledge, this is the first review about the role of this novel tumor suppressor gene BRD7in tumor development and progression. äBRD7: a novel tumor suppressor gene in different cancers (epmc).pdf DeepDyve Pubget Overpricing