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10.3390/genes7040016

http://scihub22266oqcxt.onion/10.3390/genes7040016
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suck abstract from ncbi


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pmid27110825
      Genes+(Basel) 2016 ; 7 (4 ): ä
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  • The R-Operon: A Model of Repetitive DNA-Organized Transcriptional Compartmentation of Eukaryotic Chromosomes for Coordinated Gene Expression #MMPMID27110825
  • Tang SJ
  • Genes (Basel) 2016[Apr]; 7 (4 ): ä PMID27110825 show ga
  • In eukaryotic genomes, it is essential to coordinate the activity of genes that function together to fulfill the same biological processes. Genomic organization likely plays a key role in coordinating transcription of different genes. However, little is known about how co-regulated genes are organized in the cell nucleus and how the chromosomal organization facilitates the co-regulation of different genes. I propose that eukaryotic genomes are organized into repeat assembly (RA)-based structural domains ("R-operons") in the nuclear space. R-operons result from the interaction of homologous DNA repeats. In an R-operon, genes in different loci of the linear genome are brought into spatial vicinity and co-regulated by the same pool of transcription factors. This type of large-scale chromosomal organization may provide a mechanism for functional compartmentation of chromosomes to facilitate the transcriptional coordination of gene expression.
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