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10.1039/c6mb00052e http://scihub22266oqcxt.onion/10.1039/c6mb00052e C4846559!4846559 !27004607     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27004607 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Biosyst 2016 ; 12 (5 ): 1653-66 Nephropedia Template TP {{tp|p=27004607 |t=2016. Illuminating drug action by network integration of disease genes: a case study of myocardial infarction |pdf=|usr=}}{{27004607 }} gab.com Text Illuminating drug action by network integration of disease genes: a case study of myocardial infarction JO: Mol Biosyst http://www.kidney.de/pget.php?&tw=1&pmid=27004607 #FOAvip Drug discovery has produced many successful therapeutic agents; however, most of these drugs were developed without a deep understanding of the system-wide mechanisms of action responsible for their indications. Gene-disease associations produced by molecular and genetic studies of complex diseases provide great opportunities for a system-level understanding of drug activity. In this study, we focused on acute myocardial infarction (MI) and conducted an integrative network analysis to illuminate drug actions. We integrated MI drugs, MI drug interactors, drug targets, and MI disease genes into the human interactome and showed that MI drug targets are significantly proximate to MI disease proteins. We then constructed a bipartite network of MI-related drug targets and MI disease proteins and derived 12 drug-target-disease (DTD) modules. We assessed the biological relevance of these modules and demonstrated the benefits of incorporating disease genes. The results indicate that DTD modules provide insights into the mechanisms of action of MI drugs and the cardiovascular (side) effects of non-MI drugs. Twit Text FOAVip Illuminating drug action by network integration of disease genes: a case study of myocardial infarction ????Mol Biosyst http://www.kidney.de/pget.php?&tw=1&pmid=27004607 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27004607 #FOAvip English Wikipedia <ref>{{Cite pmid|27004607 }}</ref> Illuminating drug action by network integration of disease genes: a case study of myocardial infarction #MMPMID27004607 Wang RS ; Loscalzo J Mol Biosyst 2016[Apr]; 12 (5 ): 1653-66 PMID27004607 show ga Drug discovery has produced many successful therapeutic agents; however, most of these drugs were developed without a deep understanding of the system-wide mechanisms of action responsible for their indications. Gene-disease associations produced by molecular and genetic studies of complex diseases provide great opportunities for a system-level understanding of drug activity. In this study, we focused on acute myocardial infarction (MI) and conducted an integrative network analysis to illuminate drug actions. We integrated MI drugs, MI drug interactors, drug targets, and MI disease genes into the human interactome and showed that MI drug targets are significantly proximate to MI disease proteins. We then constructed a bipartite network of MI-related drug targets and MI disease proteins and derived 12 drug-target-disease (DTD) modules. We assessed the biological relevance of these modules and demonstrated the benefits of incorporating disease genes. The results indicate that DTD modules provide insights into the mechanisms of action of MI drugs and the cardiovascular (side) effects of non-MI drugs. |*Computational Biology/methods [MESH] |*Models, Biological [MESH] |Algorithms [MESH] |Drug-Related Side Effects and Adverse Reactions [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation/*drug effects [MESH] |Gene Regulatory Networks/*drug effects [MESH] |Humans [MESH] |Myocardial Infarction/drug therapy/*genetics/metabolism [MESH] |Protein Binding [MESH] |Protein Interaction Mapping [MESH]Illuminating drug action by network integration of disease genes: a ca(epmc).pdf DeepDyve Pubget Overpricing