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10.1016/j.cub.2016.02.064 http://scihub22266oqcxt.onion/10.1016/j.cub.2016.02.064 C4846541!4846541!27020743     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Biol 2016 ; 26 (8): 1117-25 Nephropedia Template TP {{tp|p=27020743|t=2016. Local pheromone release from dynamic polarity sites underlies cell-cell pairing during yeast mating |pdf=|usr=}}{{27020743}} gab.com Text Local pheromone release from dynamic polarity sites underlies cell-cell pairing during yeast mating JO: Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=27020743 #FOAvip Cell pairing is central for many processes, including immune defense, neuronal connection, hyphal fusion or sexual reproduction. How does a cell orient towards a partner, especially when faced with multiple choices? Fission yeast Schizosaccharomyces pombe P- and M-cells, which respectively express P- and M-factor pheromones [1, 2], pair during the mating process induced by nitrogen starvation. Engagement of pheromone receptors Map3 and Mam2 [3, 4] with their cognate pheromone ligands leads to activation of the G?-protein Gpa1 to signal sexual differentiation [3, 5, 6]. Prior to cell pairing, the Cdc42 GTPase, a central regulator of cell polarization, forms dynamic zones of activity at the cell periphery at distinct locations over time [7]. Here, we show that Cdc42-GTP polarization sites contain the M-factor transporter Mam1, the general secretion machinery, which underlies P-factor secretion, and Gpa1, suggesting these are sub-cellular zones of pheromone secretion and signaling. Zone lifetimes scale with pheromone concentration. Computational simulations of pair formation through a fluctuating zone show that the combination of local pheromone release and sensing, short pheromone decay length, and pheromone-dependent zone stabilization leads to efficient pair formation. Consistently, pairing efficiency is reduced in absence of the P-factor protease. Similarly, zone stabilization at reduced pheromone levels, which occurs in absence of the predicted GTPase-activating protein for Ras, leads to reduction in pairing efficiency. We propose that efficient cell pairing relies on a fluctuating local signal emission and perception, which become locked into place through stimulation. Twit Text FOAVip Local pheromone release from dynamic polarity sites underlies cell-cell pairing during yeast mating ????Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=27020743 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27020743 #FOAvip English Wikipedia <ref>{{Cite pmid|27020743}}</ref> Local pheromone release from dynamic polarity sites underlies cell-cell pairing during yeast mating #MMPMID27020743 Merlini L; Khalili B; Bendezú FO; Hurwitz D; Vincenzetti V; Vavylonis D; Martin SG Curr Biol 2016[Apr]; 26 (8): 1117-25 PMID27020743show ga Cell pairing is central for many processes, including immune defense, neuronal connection, hyphal fusion or sexual reproduction. How does a cell orient towards a partner, especially when faced with multiple choices? Fission yeast Schizosaccharomyces pombe P- and M-cells, which respectively express P- and M-factor pheromones [1, 2], pair during the mating process induced by nitrogen starvation. Engagement of pheromone receptors Map3 and Mam2 [3, 4] with their cognate pheromone ligands leads to activation of the G?-protein Gpa1 to signal sexual differentiation [3, 5, 6]. Prior to cell pairing, the Cdc42 GTPase, a central regulator of cell polarization, forms dynamic zones of activity at the cell periphery at distinct locations over time [7]. Here, we show that Cdc42-GTP polarization sites contain the M-factor transporter Mam1, the general secretion machinery, which underlies P-factor secretion, and Gpa1, suggesting these are sub-cellular zones of pheromone secretion and signaling. Zone lifetimes scale with pheromone concentration. Computational simulations of pair formation through a fluctuating zone show that the combination of local pheromone release and sensing, short pheromone decay length, and pheromone-dependent zone stabilization leads to efficient pair formation. Consistently, pairing efficiency is reduced in absence of the P-factor protease. Similarly, zone stabilization at reduced pheromone levels, which occurs in absence of the predicted GTPase-activating protein for Ras, leads to reduction in pairing efficiency. We propose that efficient cell pairing relies on a fluctuating local signal emission and perception, which become locked into place through stimulation. äLocal pheromone release from dynamic polarity sites underlies cell-cel(epmc).pdf DeepDyve Pubget Overpricing