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10.1055/s-0036-1571835

http://scihub22266oqcxt.onion/10.1055/s-0036-1571835
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C4846411!4846411!27123385
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suck abstract from ncbi

pmid27123385      J+Neurol+Surg+B+Skull+Base 2016 ; 77 (2): 96-106
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  • Mechanisms of Perineural Invasion #MMPMID27123385
  • Bakst RL; Wong RJ
  • J Neurol Surg B Skull Base 2016[Apr]; 77 (2): 96-106 PMID27123385show ga
  • Perineural invasion (PNI) is the neoplastic invasion of nerves. PNI is widely recognized as an important adverse pathological feature of many malignancies, including pancreatic, prostate, and head and neck cancers and is associated with a poor prognosis. Despite widespread acknowledgment of the clinical significance of PNI, the mechanisms underlying its pathogenesis remain largely unknown. Recent theories of PNI pathogenesis have placed a significant emphasis on the active role of the nerve microenvironment, with PNI resulting from well-orchestrated reciprocal interactions between cancer and host. Elucidating the mechanisms involved in PNI may translate into targeted therapies for this ominous process.
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