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10.1158/0008-5472.CAN-14-2535 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-2535 C4846295!4846295 !25744723     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25744723 &cmd=llinks): Failed to open stream: HTTP request failed! 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Molecular portraits of epithelial, mesenchymal, and hybrid States in lung adenocarcinoma and their relevance to survival |pdf=|usr=}}{{25744723 }} gab.com Text Molecular portraits of epithelial, mesenchymal, and hybrid States in lung adenocarcinoma and their relevance to survival JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25744723 #FOAvip Epithelial-to-mesenchymal transition (EMT) is a key process associated with tumor progression and metastasis. To define molecular features associated with EMT states, we undertook an integrative approach combining mRNA, miRNA, DNA methylation, and proteomic profiles of 38 cell populations representative of the genomic heterogeneity in lung adenocarcinoma. The resulting data were integrated with functional profiles consisting of cell invasiveness, adhesion, and motility. A subset of cell lines that were readily defined as epithelial or mesenchymal based on their morphology and E-cadherin and vimentin expression elicited distinctive molecular signatures. Other cell populations displayed intermediate/hybrid states of EMT, with mixed epithelial and mesenchymal characteristics. A dominant proteomic feature of aggressive hybrid cell lines was upregulation of cytoskeletal and actin-binding proteins, a signature shared with mesenchymal cell lines. Cytoskeletal reorganization preceded loss of E-cadherin in epithelial cells in which EMT was induced by TGF?. A set of transcripts corresponding to the mesenchymal protein signature enriched in cytoskeletal proteins was found to be predictive of survival in independent datasets of lung adenocarcinomas. Our findings point to an association between cytoskeletal and actin-binding proteins, a mesenchymal or hybrid EMT phenotype and invasive properties of lung adenocarcinomas. Twit Text FOAVip Molecular portraits of epithelial, mesenchymal, and hybrid States in lung adenocarcinoma and their relevance to survival ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25744723 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25744723 #FOAvip English Wikipedia <ref>{{Cite pmid|25744723 }}</ref> Molecular portraits of epithelial, mesenchymal, and hybrid States in lung adenocarcinoma and their relevance to survival #MMPMID25744723 Schliekelman MJ ; Taguchi A ; Zhu J ; Dai X ; Rodriguez J ; Celiktas M ; Zhang Q ; Chin A ; Wong CH ; Wang H ; McFerrin L ; Selamat SA ; Yang C ; Kroh EM ; Garg KS ; Behrens C ; Gazdar AF ; Laird-Offringa IA ; Tewari M ; Wistuba II ; Thiery JP ; Hanash SM Cancer Res 2015[May]; 75 (9 ): 1789-800 PMID25744723 show ga Epithelial-to-mesenchymal transition (EMT) is a key process associated with tumor progression and metastasis. To define molecular features associated with EMT states, we undertook an integrative approach combining mRNA, miRNA, DNA methylation, and proteomic profiles of 38 cell populations representative of the genomic heterogeneity in lung adenocarcinoma. The resulting data were integrated with functional profiles consisting of cell invasiveness, adhesion, and motility. A subset of cell lines that were readily defined as epithelial or mesenchymal based on their morphology and E-cadherin and vimentin expression elicited distinctive molecular signatures. Other cell populations displayed intermediate/hybrid states of EMT, with mixed epithelial and mesenchymal characteristics. A dominant proteomic feature of aggressive hybrid cell lines was upregulation of cytoskeletal and actin-binding proteins, a signature shared with mesenchymal cell lines. Cytoskeletal reorganization preceded loss of E-cadherin in epithelial cells in which EMT was induced by TGF?. A set of transcripts corresponding to the mesenchymal protein signature enriched in cytoskeletal proteins was found to be predictive of survival in independent datasets of lung adenocarcinomas. Our findings point to an association between cytoskeletal and actin-binding proteins, a mesenchymal or hybrid EMT phenotype and invasive properties of lung adenocarcinomas. |Adenocarcinoma of Lung [MESH] |Adenocarcinoma/genetics/*metabolism/*pathology [MESH] |Cadherins/metabolism [MESH] |Cell Adhesion/genetics [MESH] |Cell Line, Tumor [MESH] |Cell Movement/genetics [MESH] |Cell Survival/genetics/*physiology [MESH] |Cytoskeleton/metabolism [MESH] |DNA Methylation [MESH] |Epithelial Cells/*metabolism/pathology [MESH] |Epithelial-Mesenchymal Transition/genetics/*physiology [MESH] |Humans [MESH] |Lung Neoplasms/genetics/*metabolism/*pathology [MESH] |MicroRNAs/genetics [MESH] |Microfilament Proteins/metabolism [MESH] |Proteomics/methods [MESH] |Transforming Growth Factor beta/metabolism [MESH] |Up-Regulation [MESH]Molecular portraits of epithelial, mesenchymal, and hybrid States in l(epmc).pdf DeepDyve Pubget Overpricing