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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Br+J+Radiol
2016 ; 89
(1060
): 20150650
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Modic changes in lumbar spine: prevalence and distribution patterns of end plate
oedema and end plate sclerosis
#MMPMID26828968
Xu L
; Chu B
; Feng Y
; Xu F
; Zou YF
Br J Radiol
2016[]; 89
(1060
): 20150650
PMID26828968
show ga
OBJECTIVE: The purpose of this study is to evaluate the distribution of end plate
oedema in different types of Modic change especially in mixed type and to analyze
the presence of end plate sclerosis in various types of Modic change. MATERIALS
AND METHODS: 276 patients with low back pain were scanned with 1.5-T MRI. Three
radiologists assessed the MR images by T1 weighted, T2 weighted and
fat-saturation T2 weighted sequences and classified them according to the Modic
changes. Pure oedematous end plate signal changes were classified as Modic Type
I; pure fatty end plate changes were classified as Modic Type II; and pure
sclerotic end plate changes as Modic Type III. A mixed feature of both Types I
and II with predominant oedematous signal change is classified as Modic I-II, and
a mixture of Types I and II with predominant fatty change is classified as Modic
II-I. Thus, the mixed types can further be subdivided into seven subtypes: Types
I-II, Types II-I, Types I-III, Types III-I, Types II-III, Types III-II and Types
I-III. During the same period, 52 of 276 patients who underwent CT and MRI were
retrospectively reviewed to determine end plate sclerosis. RESULTS: (1) End plate
oedema: of the 2760 end plates (276 patients) examined, 302 end plates showed
Modic changes, of which 82 end plates showed mixed Modic changes. The mixed Modic
changes contain 92.7% of oedematous changes. The mixed types especially Types
I-II and Types II-I made up the majority of end plate oedematous changes. (2) End
plate sclerosis: 52 of 276 patients were examined by both MRI and CT. Of the 520
end plates, 93 end plates showed Modic changes, of which 34 end plates have shown
sclerotic changes in CT images. 11.8% of 34 end plates have shown Modic Type I,
20.6% of 34 end plates have shown Modic Type II, 2.9% of 34 end plates have shown
Modic Type III and 64.7% of 34 end plates have shown mixed Modic type.
CONCLUSION: End plate oedema makes up the majority of mixed types especially
Types I-II and Types II-I. The end plate sclerosis on CT images may not just mean
Modic Type III but does exist in all types of Modic changes, especially in mixed
Modic types, and may reflect vertebral body mineralization rather than change in
the bone marrow. ADVANCES IN KNOWLEDGE: End plate oedema and end plate sclerosis
are present in a large proportion of mixed types.