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10.1080/15384101.2016.1148837 http://scihub22266oqcxt.onion/10.1080/15384101.2016.1148837 C4845946!4845946!26890356     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Cycle 2016 ; 15 (5): 699-710 Nephropedia Template TP {{tp|p=26890356|t=2016. Repression of Wnt/?-catenin response elements by p63 (TP63) |pdf=|usr=}}{{26890356}} gab.com Text Repression of Wnt/ -catenin response elements by p63 (TP63) JO: Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=26890356 #FOAvip Submitted: TP63 (p63), a member of the tumor suppressor TP53 (p53) gene family, is expressed in keratinocyte stem cells and well-differentiated squamous cell carcinomas to maintain cellular potential for growth and differentiation. Controversially, activation of the Wnt/?-catenin signaling by p63 (Patturajan M. et al., 2002, Cancer Cells) and inhibition of the target gene expression (Drewelus I. et al., 2010, Cell Cycle) have been reported. Upon p63 RNA-silencing in squamous cell carcinoma (SCC) lines, a few Wnt target gene expression substantially increased, while several target genes moderately decreased. Although ?Np63?, the most abundant isoform of p63, appeared to interact with protein phosphatase PP2A, neither GSK-3? phosphorylation nor ?-catenin nuclear localization was altered by the loss of p63. As reported earlier, ?Np63? enhanced ?-catenin-dependent luc gene expression from pGL3-OT having 3 artificial Wnt response elements (WREs). However, this activation was detectable only in HEK293 cells examined so far, and involved a p53 family-related sequence 5? to the WREs. In Wnt3-expressing SAOS-2 cells, ?Np63? rather strongly inhibited transcription of pGL3-OT. Importantly, ?Np63? repressed WREs isolated from the regulatory regions of MMP7. ?Np63?-TCF4 association occurred in their soluble forms in the nucleus. Furthermore, p63 and TCF4 coexisted at a WRE of MMP7 on the chromatin, where ?-catenin recruitment was attenuated. The combined results indicate that ?Np63? serves as a repressor that regulates ?-catenin-mediated gene expression. Twit Text FOAVip Repression of Wnt/ -catenin response elements by p63 (TP63) ????Cell Cycle http://www.kidney.de/pget.php?&tw=1&pmid=26890356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26890356 #FOAvip English Wikipedia <ref>{{Cite pmid|26890356}}</ref> Repression of Wnt/?-catenin response elements by p63 (TP63) #MMPMID26890356 Katoh I; Fukunishi N; Fujimuro M; Kasai H; Moriishi K; Hata RI; Kurata Si Cell Cycle 2016[]; 15 (5): 699-710 PMID26890356show ga Submitted: TP63 (p63), a member of the tumor suppressor TP53 (p53) gene family, is expressed in keratinocyte stem cells and well-differentiated squamous cell carcinomas to maintain cellular potential for growth and differentiation. Controversially, activation of the Wnt/?-catenin signaling by p63 (Patturajan M. et al., 2002, Cancer Cells) and inhibition of the target gene expression (Drewelus I. et al., 2010, Cell Cycle) have been reported. Upon p63 RNA-silencing in squamous cell carcinoma (SCC) lines, a few Wnt target gene expression substantially increased, while several target genes moderately decreased. Although ?Np63?, the most abundant isoform of p63, appeared to interact with protein phosphatase PP2A, neither GSK-3? phosphorylation nor ?-catenin nuclear localization was altered by the loss of p63. As reported earlier, ?Np63? enhanced ?-catenin-dependent luc gene expression from pGL3-OT having 3 artificial Wnt response elements (WREs). However, this activation was detectable only in HEK293 cells examined so far, and involved a p53 family-related sequence 5? to the WREs. In Wnt3-expressing SAOS-2 cells, ?Np63? rather strongly inhibited transcription of pGL3-OT. Importantly, ?Np63? repressed WREs isolated from the regulatory regions of MMP7. ?Np63?-TCF4 association occurred in their soluble forms in the nucleus. Furthermore, p63 and TCF4 coexisted at a WRE of MMP7 on the chromatin, where ?-catenin recruitment was attenuated. The combined results indicate that ?Np63? serves as a repressor that regulates ?-catenin-mediated gene expression. äRepression of Wnt/?-catenin response elements by p63 (TP63) (epmc).pdf DeepDyve Pubget Overpricing