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2016 ; 2016
(4
): 86-90
Nephropedia Template TP
gab.com Text
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Polyarteritis nodosa Diagnostic challenges in a patient with cutaneous
vasculitis, psoriasis, psoriatic arthritis and pancytopenia: fatal progression
after treatment with G-CSF
#MMPMID27123310
Jobanputra P
Oxf Med Case Reports
2016[Apr]; 2016
(4
): 86-90
PMID27123310
show ga
A 60-year-old man presented with cutaneous vasculitis, leucopenia and psoriasis.
He was treated initially with ciclosporin A. On withdrawal of ciclosporin, due to
inadequate improvement of cutaneous vasculitis, he developed psoriatic arthritis.
Worsening neutropenia and pancytopenia, believed to be immune mediated,
developed. He was treated with prednisolone, methotrexate and adalimumab but
developed pneumocystis pneumonia. Leucocyte levels improved markedly with
granulocyte colony-stimulating factor (G-CSF). However, whilst being treated with
G-CSF his condition deteriorated. He developed gastrointestinal and neurological
symptoms and progressive weight loss. Diagnosis was delayed, but eventually
polyarteritis nodosa was diagnosed and he was treated with cyclophosphamide. The
patient improved initially but died from small bowel perforation due to
vasculitis. Evidence showing a temporal association of his deterioration with use
of G-CSF is shown. The use of G-CSF in patients with autoimmune conditions
including vasculitis should be undertaken with great caution.