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10.3389/fimmu.2016.00155

http://scihub22266oqcxt.onion/10.3389/fimmu.2016.00155
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C4844928!4844928!27199981
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suck abstract from ncbi


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pmid27199981      Front+Immunol 2016 ; 7 (ä): ä
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  • Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious #MMPMID27199981
  • Sônego F; Castanheira FVe S; Ferreira RG; Kanashiro A; Leite CAVG; Nascimento DC; Colón DF; Borges Vde F; Alves-Filho JC; Cunha FQ
  • Front Immunol 2016[]; 7 (ä): ä PMID27199981show ga
  • Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of the costliest and deadliest medical conditions worldwide. Neutrophils are classically considered to be essential players in the host defense against invading pathogens. However, several investigations have shown that impairment of neutrophil migration to the site of infection, also referred to as neutrophil paralysis, occurs during severe sepsis, resulting in an inability of the host to contain and eliminate the infection. On the other hand, the neutrophil antibacterial arsenal contributes to tissue damage and the development of organ dysfunction during sepsis. In this review, we provide an overview of the main events in which neutrophils play a beneficial or deleterious role in the outcome of sepsis.
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