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10.1371/journal.pone.0154256 http://scihub22266oqcxt.onion/10.1371/journal.pone.0154256 C4844248!4844248!27111220     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2016 ; 11 (4): ä Nephropedia Template TP {{tp|p=27111220|t=2016. Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients |pdf=|usr=}}{{27111220}} gab.com Text Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27111220 #FOAvip Insulin-like growth factor (IGF) signalling plays a key role in homing, progression, and treatment resistance in multiple myeloma (MM). In the extracellular environment, the majority of IGF molecules are bound to one of six IGF-binding proteins (IGFBP1-6), leaving a minor fraction of total IGF free and accessible for receptor activation. In MM, high IGF-receptor type 1 expression levels correlate with a poor prognosis, but the status and role of IGF and IGFBPs in the pathobiology of MM is unknown. Here we measured total IGF1, IGF2, and intact IGFBP levels in blood and bone marrow samples from MM (n = 17), monoclonal gammopathy of undetermined significance (MGUS) (n = 37), and control individuals (n = 15), using ELISA (IGFs) and 125I-IGF1 Western Ligand Blotting (IGFBPs). MGUS and MM patients displayed a significant increase in intact IGFBP-2 (2.5?3.8 fold) and decrease in intact IGFBP-3 (0.6?0.5 fold) in the circulation compared to control individuals. Further, IGFBP-2 as well as total IGFBP levels were significantly lower in bone marrow compared to circulation in MM and MGUS only, whereas IGF1, IGF2, and IGFBP-3 were equally distributed between the two compartments. In conclusion, the profound change in IGFBP profile strongly suggests an increased IGF bioavailability in the bone marrow microenvironment in MGUS and MM, despite no change in growth factor concentration. Twit Text FOAVip Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27111220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27111220 #FOAvip English Wikipedia <ref>{{Cite pmid|27111220}}</ref> Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients #MMPMID27111220 Bieghs L; Brohus M; Kristensen IB; Abildgaard N; Bøgsted M; Johnsen HE; Conover CA; De Bruyne E; Vanderkerken K; Overgaard MT; Nyegaard M PLoS One 2016[]; 11 (4): ä PMID27111220show ga Insulin-like growth factor (IGF) signalling plays a key role in homing, progression, and treatment resistance in multiple myeloma (MM). In the extracellular environment, the majority of IGF molecules are bound to one of six IGF-binding proteins (IGFBP1-6), leaving a minor fraction of total IGF free and accessible for receptor activation. In MM, high IGF-receptor type 1 expression levels correlate with a poor prognosis, but the status and role of IGF and IGFBPs in the pathobiology of MM is unknown. Here we measured total IGF1, IGF2, and intact IGFBP levels in blood and bone marrow samples from MM (n = 17), monoclonal gammopathy of undetermined significance (MGUS) (n = 37), and control individuals (n = 15), using ELISA (IGFs) and 125I-IGF1 Western Ligand Blotting (IGFBPs). MGUS and MM patients displayed a significant increase in intact IGFBP-2 (2.5?3.8 fold) and decrease in intact IGFBP-3 (0.6?0.5 fold) in the circulation compared to control individuals. Further, IGFBP-2 as well as total IGFBP levels were significantly lower in bone marrow compared to circulation in MM and MGUS only, whereas IGF1, IGF2, and IGFBP-3 were equally distributed between the two compartments. In conclusion, the profound change in IGFBP profile strongly suggests an increased IGF bioavailability in the bone marrow microenvironment in MGUS and MM, despite no change in growth factor concentration. äAbnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple My(epmc).pdf DeepDyve Pubget Overpricing