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10.4161/23328940.2014.988524 http://scihub22266oqcxt.onion/10.4161/23328940.2014.988524 C4844244!4844244!27227024     free     free     free       Temperature+(Austin) 2015 ; 2 (2): 201-13 Nephropedia Template TP {{tp|p=27227024|t=2015. TRPM3 in temperature sensing and beyond |pdf=|usr=}}{{27227024}} gab.com Text TRPM3 in temperature sensing and beyond JO: Temperature (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=27227024 #FOAvip TRPM3, also known as melastatin 2 (MLSN2), LTRPC3 (long TRPC3) and KIAA1616, is a member of the TRPM subfamily of transient receptor potential (TRP) ion channels. The channel was originally identified as a volume-regulated ion channel that can be activated upon reduction of the extracellular osmolality. Later, the channel was proposed to be involved in the modulation of insulin release in pancreatic islets. However, new evidence has uncovered a role of TRPM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat. The channel is functionally expressed in a subset of neurons of the somatosensory system and can be activated by heat. The purpose of the present review is to summarize existing knowledge of the expression, biophysics and pharmacology of TRPM3 and to serve as a guide for future studies aimed at improving the understanding of the mechanism of thermosensation and proposed physiological functions of TRPM3. Twit Text FOAVip TRPM3 in temperature sensing and beyond ????Temperature (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=27227024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27227024 #FOAvip English Wikipedia <ref>{{Cite pmid|27227024}}</ref> TRPM3 in temperature sensing and beyond #MMPMID27227024 Held K; Voets T; Vriens J Temperature (Austin) 2015[Apr]; 2 (2): 201-13 PMID27227024show ga TRPM3, also known as melastatin 2 (MLSN2), LTRPC3 (long TRPC3) and KIAA1616, is a member of the TRPM subfamily of transient receptor potential (TRP) ion channels. The channel was originally identified as a volume-regulated ion channel that can be activated upon reduction of the extracellular osmolality. Later, the channel was proposed to be involved in the modulation of insulin release in pancreatic islets. However, new evidence has uncovered a role of TRPM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat. The channel is functionally expressed in a subset of neurons of the somatosensory system and can be activated by heat. The purpose of the present review is to summarize existing knowledge of the expression, biophysics and pharmacology of TRPM3 and to serve as a guide for future studies aimed at improving the understanding of the mechanism of thermosensation and proposed physiological functions of TRPM3. äTRPM3 in temperature sensing and beyond (epmc).pdf DeepDyve Pubget Overpricing