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10.1038/nature17644 http://scihub22266oqcxt.onion/10.1038/nature17644 C4844022!4844022!27049946     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2016 ; 532 (7598): 201-6 Nephropedia Template TP {{tp|p=27049946|t=2016. Modulation of tissue repair by regeneration enhancer elements |pdf=|usr=}}{{27049946}} gab.com Text Modulation of tissue repair by regeneration enhancer elements JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=27049946 #FOAvip How tissue regeneration programs are triggered by injury has received limited research attention. Here, we investigated the existence of enhancer regulatory elements that engage in regenerating tissue. Transcriptome analyses revealed that leptin b (lepb) is sharply induced in regenerating hearts and fins of zebrafish. Epigenetic profiling identified a short DNA sequence element upstream and distal to lepb that acquires open chromatin marks during regeneration and enables injury-dependent expression from minimal promoters. This element could activate expression in injured neonatal mouse tissues and was divisible into tissue-specific modules sufficient for expression in regenerating zebrafish fins or hearts. Simple enhancer-effector transgenes employing lepb-linked sequences upstream of pro- or anti-regenerative factors controlled the efficacy of regeneration in zebrafish. Our findings provide evidence for tissue regeneration enhancer elements (TREEs) that trigger gene expression in injury sites and can be engineered to modulate the regenerative potential of vertebrate organs. Twit Text FOAVip Modulation of tissue repair by regeneration enhancer elements ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=27049946 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27049946 #FOAvip English Wikipedia <ref>{{Cite pmid|27049946}}</ref> Modulation of tissue repair by regeneration enhancer elements #MMPMID27049946 Kang J; Hu J; Karra R; Dickson AL; Tornini VA; Nachtrab G; Gemberling M; Goldman JA; Black BL; Poss KD Nature 2016[Apr]; 532 (7598): 201-6 PMID27049946show ga How tissue regeneration programs are triggered by injury has received limited research attention. Here, we investigated the existence of enhancer regulatory elements that engage in regenerating tissue. Transcriptome analyses revealed that leptin b (lepb) is sharply induced in regenerating hearts and fins of zebrafish. Epigenetic profiling identified a short DNA sequence element upstream and distal to lepb that acquires open chromatin marks during regeneration and enables injury-dependent expression from minimal promoters. This element could activate expression in injured neonatal mouse tissues and was divisible into tissue-specific modules sufficient for expression in regenerating zebrafish fins or hearts. Simple enhancer-effector transgenes employing lepb-linked sequences upstream of pro- or anti-regenerative factors controlled the efficacy of regeneration in zebrafish. Our findings provide evidence for tissue regeneration enhancer elements (TREEs) that trigger gene expression in injury sites and can be engineered to modulate the regenerative potential of vertebrate organs. äModulation of tissue repair by regeneration enhancer elements (epmc).pdf DeepDyve Pubget Overpricing