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10.1002/eji.201444983 http://scihub22266oqcxt.onion/10.1002/eji.201444983 C4843951!4843951 !25487358     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25487358 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Immunol 2015 ; 45 (3 ): 747-57 Nephropedia Template TP {{tp|p=25487358 |t=2015. Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B-cell responses |pdf=|usr=}}{{25487358 }} gab.com Text Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B-cell responses JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25487358 #FOAvip Ag delivery to specific APCs is an attractive approach in developing strategies for vaccination. CD169(+) macrophages in the marginal zone of the spleen represent a suitable target for delivery of Ag because of their strategic location, which is optimal for the capture of blood-borne Ag and their close proximity to B cells and T cells in the white pulp. Here we show that Ag targeting to CD169(+) macrophages in mice resulted in strong, isotype-switched, high-affinity Ab production and the preferential induction and long-term persistence of Ag-specific GC B cells and follicular Th cells. In agreement with these observations, CD169(+) macrophages retained intact Ag, induced cognate activation of B cells, and increased expression of costimulatory molecules upon activation. In addition, macrophages were required for the production of cytokines that promote B-cell responses. Our results identify CD169(+) macrophages as promoters of high-affinity humoral immune responses and emphasize the value of CD169 as target for Ag delivery to improve vaccine responses. Twit Text FOAVip Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B-cell responses ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25487358 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25487358 #FOAvip English Wikipedia <ref>{{Cite pmid|25487358 }}</ref> Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B-cell responses #MMPMID25487358 Veninga H ; Borg EG ; Vreeman K ; Taylor PR ; Kalay H ; van Kooyk Y ; Kraal G ; Martinez-Pomares L ; den Haan JM Eur J Immunol 2015[Mar]; 45 (3 ): 747-57 PMID25487358 show ga Ag delivery to specific APCs is an attractive approach in developing strategies for vaccination. CD169(+) macrophages in the marginal zone of the spleen represent a suitable target for delivery of Ag because of their strategic location, which is optimal for the capture of blood-borne Ag and their close proximity to B cells and T cells in the white pulp. Here we show that Ag targeting to CD169(+) macrophages in mice resulted in strong, isotype-switched, high-affinity Ab production and the preferential induction and long-term persistence of Ag-specific GC B cells and follicular Th cells. In agreement with these observations, CD169(+) macrophages retained intact Ag, induced cognate activation of B cells, and increased expression of costimulatory molecules upon activation. In addition, macrophages were required for the production of cytokines that promote B-cell responses. Our results identify CD169(+) macrophages as promoters of high-affinity humoral immune responses and emphasize the value of CD169 as target for Ag delivery to improve vaccine responses. |Animals [MESH] |Antibody Formation/*physiology [MESH] |B-Lymphocytes/cytology/*immunology [MESH] |Germinal Center/cytology/*immunology [MESH] |Lymphocyte Activation/*physiology [MESH] |Mice [MESH] |Mice, Mutant Strains [MESH] |Sialic Acid Binding Ig-like Lectin 1/genetics/*immunology [MESH] |Spleen/cytology/*immunology [MESH]Antigen targeting reveals splenic CD169+ macrophages as promoters of g(epmc).pdf DeepDyve Pubget Overpricing