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10.1161/JAHA.115.002648 http://scihub22266oqcxt.onion/10.1161/JAHA.115.002648 C4843545!4843545 !27107135     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27107135 &cmd=llinks): Failed to open stream: HTTP request failed! 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Resveratrol Ameliorates Cardiac Hypertrophy by Down-regulation of miR-155 Through Activation of Breast Cancer Type 1 Susceptibility Protein |pdf=|usr=}}{{27107135 }} gab.com Text Resveratrol Ameliorates Cardiac Hypertrophy by Down-regulation of miR-155 Through Activation of Breast Cancer Type 1 Susceptibility Protein JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=27107135 #FOAvip BACKGROUND: The polyphenol resveratrol (Rev) has been reported to exhibit cardioprotective effects, such as inhibition of TAC (transverse aortic constriction) or isoprenaline (ISO)-induced hypertrophy. MicroRNA-155 (miR-155) was found to be decreased in hypertrophic myocardium, which could be further reduced by pretreatment of Rev. The study was designed to investigate the molecular effects of miR-155 on cardiac hypertrophy, focusing on the role of breast cancer type 1 susceptibility protein (BRCA1). METHODS AND RESULTS: We demonstrated that Rev alleviated severity of hypertrophic myocardium in a mice model of cardiac hypertrophy by TAC treatment. Down-regulation of miR-155 was observed in pressure overload- or ISO-induced hypertrophic cardiomyoctyes. Interestingly, administration of Rev substantially attenuated miR-155 level in cardiomyocytes. In agreement with its miR-155 reducing effect, Rev relieved cardiac hypertrophy and restored cardiac function by activation of BRCA1 in cardiomyoctyes. Our results further revealed that forkhead box O3a (FoxO3a) was a miR-155 target in the heart. And miR-155 directly repressed FoxO3a, whose expression was mitigated in miR-155 agomir and mimic treatment in vivo and in vitro. CONCLUSIONS: We conclude that BRCA1 inactivation can increase expression of miR-155, contributing to cardiac hypertrophy. And Rev produces their beneficial effects partially by down-regulating miR-155 expression, which might be a novel strategy for treatment of cardiac hypertrophy. Twit Text FOAVip Resveratrol Ameliorates Cardiac Hypertrophy by Down-regulation of miR-155 Through Activation of Breast Cancer Type 1 Susceptibility Protein ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=27107135 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27107135 #FOAvip English Wikipedia <ref>{{Cite pmid|27107135 }}</ref> Resveratrol Ameliorates Cardiac Hypertrophy by Down-regulation of miR-155 Through Activation of Breast Cancer Type 1 Susceptibility Protein #MMPMID27107135 Fan Y ; Liu L ; Fang K ; Huang T ; Wan L ; Liu Y ; Zhang S ; Yan D ; Li G ; Gao Y ; Lv Y ; Chen Y ; Tu Y J Am Heart Assoc 2016[Apr]; 5 (4 ): ä PMID27107135 show ga BACKGROUND: The polyphenol resveratrol (Rev) has been reported to exhibit cardioprotective effects, such as inhibition of TAC (transverse aortic constriction) or isoprenaline (ISO)-induced hypertrophy. MicroRNA-155 (miR-155) was found to be decreased in hypertrophic myocardium, which could be further reduced by pretreatment of Rev. The study was designed to investigate the molecular effects of miR-155 on cardiac hypertrophy, focusing on the role of breast cancer type 1 susceptibility protein (BRCA1). METHODS AND RESULTS: We demonstrated that Rev alleviated severity of hypertrophic myocardium in a mice model of cardiac hypertrophy by TAC treatment. Down-regulation of miR-155 was observed in pressure overload- or ISO-induced hypertrophic cardiomyoctyes. Interestingly, administration of Rev substantially attenuated miR-155 level in cardiomyocytes. In agreement with its miR-155 reducing effect, Rev relieved cardiac hypertrophy and restored cardiac function by activation of BRCA1 in cardiomyoctyes. Our results further revealed that forkhead box O3a (FoxO3a) was a miR-155 target in the heart. And miR-155 directly repressed FoxO3a, whose expression was mitigated in miR-155 agomir and mimic treatment in vivo and in vitro. CONCLUSIONS: We conclude that BRCA1 inactivation can increase expression of miR-155, contributing to cardiac hypertrophy. And Rev produces their beneficial effects partially by down-regulating miR-155 expression, which might be a novel strategy for treatment of cardiac hypertrophy. |*Down-Regulation [MESH] |*Gene Expression Regulation [MESH] |Animals [MESH] |BRCA1 Protein/*genetics/metabolism [MESH] |Blotting, Western [MESH] |Cardiomegaly/drug therapy/*genetics/metabolism [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Enzyme Inhibitors/pharmacology [MESH] |Immunohistochemistry [MESH] |Male [MESH] |Mice [MESH] |MicroRNAs/biosynthesis/*genetics [MESH] |Myocytes, Cardiac/*metabolism/pathology [MESH] |RNA/genetics [MESH] |Resveratrol [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]Resveratrol Ameliorates Cardiac Hypertrophy by Down-regulation of miR-(epmc).pdf DeepDyve Pubget Overpricing