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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Matrix+Biol 2016 ; 51 (ä): 7-13 Nephropedia Template TP
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Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells #MMPMID26807758
Prockop DJ
Matrix Biol 2016[Apr]; 51 (ä): 7-13 PMID26807758show ga
Fibrosis and scarring are the end stage of many disease processes. In effect, the collagen fibers that initially provide a necessary strength during the repair of injured tissues are frequently synthesized in excessive amounts and become irreversible fibrotic deposits that limit regeneration of the endogenous cells of a tissue. This review will focus on the potential of mesenchymal stem/stromal cells for treatment of fibrotic diseases, with emphasis on the role of TSG-6 as a mediator of anti-inflammatory effects.