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10.1038/onc.2015.469 http://scihub22266oqcxt.onion/10.1038/onc.2015.469 C4842009!4842009 !26640150     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26640150 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncogene 2016 ; 35 (33 ): 4407-13 Nephropedia Template TP {{tp|p=26640150 |t=2016. Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis |pdf=|usr=}}{{26640150 }} gab.com Text Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=26640150 #FOAvip The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small. There is a need to discover new potential actionable genetic lesions, to which end, non-conventional cancer pathways, such as RNA editing, are worth exploring. Herein we show that the adenosine-to-inosine editing enzyme ADAR1 undergoes gene amplification in non-small cancer cell lines and primary tumors in association with higher levels of the corresponding mRNA and protein. From a growth and invasion standpoint, the depletion of ADAR1 expression in amplified cells reduces their tumorigenic potential in cell culture and mouse models, whereas its overexpression has the opposite effects. From a functional perspective, ADAR1 overexpression enhances the editing frequencies of target transcripts such as NEIL1 and miR-381. In the clinical setting, patients with early-stage lung cancer, but harboring ADAR1 gene amplification, have poor outcomes. Overall, our results indicate a role for ADAR1 as a lung cancer oncogene undergoing gene amplification-associated activation that affects downstream RNA editing patterns and patient prognosis. Twit Text FOAVip Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=26640150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26640150 #FOAvip English Wikipedia <ref>{{Cite pmid|26640150 }}</ref> Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis #MMPMID26640150 Anadón C ; Guil S ; Simó-Riudalbas L ; Moutinho C ; Setien F ; Martínez-Cardús A ; Moran S ; Villanueva A ; Calaf M ; Vidal A ; Lazo PA ; Zondervan I ; Savola S ; Kohno T ; Yokota J ; Ribas de Pouplana L ; Esteller M Oncogene 2016[Aug]; 35 (33 ): 4407-13 PMID26640150 show ga The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small. There is a need to discover new potential actionable genetic lesions, to which end, non-conventional cancer pathways, such as RNA editing, are worth exploring. Herein we show that the adenosine-to-inosine editing enzyme ADAR1 undergoes gene amplification in non-small cancer cell lines and primary tumors in association with higher levels of the corresponding mRNA and protein. From a growth and invasion standpoint, the depletion of ADAR1 expression in amplified cells reduces their tumorigenic potential in cell culture and mouse models, whereas its overexpression has the opposite effects. From a functional perspective, ADAR1 overexpression enhances the editing frequencies of target transcripts such as NEIL1 and miR-381. In the clinical setting, patients with early-stage lung cancer, but harboring ADAR1 gene amplification, have poor outcomes. Overall, our results indicate a role for ADAR1 as a lung cancer oncogene undergoing gene amplification-associated activation that affects downstream RNA editing patterns and patient prognosis. |*Gene Amplification [MESH] |*RNA Editing [MESH] |Adenosine Deaminase/*genetics [MESH] |Cell Line, Tumor [MESH] |Humans [MESH] |Lung Neoplasms/*etiology/genetics [MESH] |Oncogenes [MESH] |Proto-Oncogene Proteins p21(ras)/genetics [MESH]Gene amplification-associated overexpression of the RNA editing enzyme(epmc).pdf DeepDyve Pubget Overpricing