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10.1007/s00467-015-3228-x http://scihub22266oqcxt.onion/10.1007/s00467-015-3228-x C4841758!4841758!26493068     free     free     free       Pediatr+Nephrol 2016 ; 31 (7): 1055-60 Nephropedia Template TP {{tp|p=26493068|t=2016. Epigenetics mechanisms in renal development |pdf=|usr=}}{{26493068}} gab.com Text Epigenetics mechanisms in renal development JO: Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26493068 #FOAvip Appreciation for the role of epigenetic modifications in the diagnosis and treatment of diseases is fast gaining attention. Treatment of chronic kidney disease stemming from diabetes or hypertension as well as Wilm?s tumor will all profit from knowledge of the changes in the epigenomic landscapes. To do so it is essential to characterize the epigenomic modifiers and their modifications under normal physiological conditions. The transcription factor Pax2 was identified as a major epigenetic player in the early specification of the kidney. Notably, the progenitors of all nephrons that reside in the cap mesenchyme display a unique bivalent histone signature (expressing repressive epigenetic marks alongside activation marks) on lineage-specific genes. These cells are deemed poised for differentiation and commitment to the nephrogenic lineage. In response to the appropriate inducing signal, these genes lose their repressive histone marks, which allow for their expression in nascent nephron precursors. Such knowledge of the epigenetic landscape and the resultant cell fate or behavior in the developing kidney will greatly improve the overall success in designing regenerative strategies and tissue reprogramming methodologies from pluripotent cells. Twit Text FOAVip Epigenetics mechanisms in renal development ????Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26493068 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26493068 #FOAvip English Wikipedia <ref>{{Cite pmid|26493068}}</ref> Epigenetics mechanisms in renal development #MMPMID26493068 Hilliard SA; El-Dahr SS Pediatr Nephrol 2016[Jul]; 31 (7): 1055-60 PMID26493068show ga Appreciation for the role of epigenetic modifications in the diagnosis and treatment of diseases is fast gaining attention. Treatment of chronic kidney disease stemming from diabetes or hypertension as well as Wilm?s tumor will all profit from knowledge of the changes in the epigenomic landscapes. To do so it is essential to characterize the epigenomic modifiers and their modifications under normal physiological conditions. The transcription factor Pax2 was identified as a major epigenetic player in the early specification of the kidney. Notably, the progenitors of all nephrons that reside in the cap mesenchyme display a unique bivalent histone signature (expressing repressive epigenetic marks alongside activation marks) on lineage-specific genes. These cells are deemed poised for differentiation and commitment to the nephrogenic lineage. In response to the appropriate inducing signal, these genes lose their repressive histone marks, which allow for their expression in nascent nephron precursors. Such knowledge of the epigenetic landscape and the resultant cell fate or behavior in the developing kidney will greatly improve the overall success in designing regenerative strategies and tissue reprogramming methodologies from pluripotent cells. äEpigenetics mechanisms in renal development (epmc).pdf DeepDyve Pubget Overpricing