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10.1038/nrm.2016.27

http://scihub22266oqcxt.onion/10.1038/nrm.2016.27
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C4841706!4841706!27033256
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suck abstract from ncbi


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pmid27033256      Nat+Rev+Mol+Cell+Biol 2016 ; 17 (5): 280-92
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  • Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases #MMPMID27033256
  • Hydbring P; Malumbres M; Sicinski P
  • Nat Rev Mol Cell Biol 2016[May]; 17 (5): 280-92 PMID27033256show ga
  • The role of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as core components of the machinery that drives cell cycle progression is well established. Increasing evidence indicates that mammalian cyclins and CDKs also carry out important roles in other cellular processes such as transcription, DNA damage repair, the control of cell death, differentiation, the immune response and metabolism. Some of these non-canonical functions are performed by cyclins or by CDKs, independent of their respective cell cycle partners, suggesting a substantial divergence in the function of these proteins during evolution.
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