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10.1080/15476286.2016.1152439 http://scihub22266oqcxt.onion/10.1080/15476286.2016.1152439 C4841609!4841609!26909464     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       RNA+Biol 2016 ; 13 (4): 367-72 Nephropedia Template TP {{tp|p=26909464|t=2016. Non-coding RNAs, the cutting edge of histone messages |pdf=|usr=}}{{26909464}} gab.com Text Non-coding RNAs, the cutting edge of histone messages JO: RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=26909464 #FOAvip In metazoan the 3?-end processing of histone mRNAs is a conserved process involving the concerted action of many protein factors and the non-coding U7 snRNA. Recently, we identified that the processing of histone pre-mRNAs is promoted by an additional ncRNA, the Y3-derived Y3** RNA. U7 modulates the association of the U7 snRNP whereas Y3** promotes recruitment of CPSF (cleavage and polyadenylation specific factor) proteins to nascent histone transcripts at histone locus bodies (HLBs) in mammals. This enhances the 3?-end cleavage of nascent histone pre-mRNAs and modulates HLB assembly. Here we discuss new insights in the role of ncRNAs in the spatiotemporal control of histone synthesis. We propose that ncRNAs scaffold the formation of functional protein-RNA complexes and their sequential deposition on nascent histone pre-mRNAs at HLBs. These findings add to the multiple roles of ncRNAs in controlling gene expression and may provide new avenues for targeting histone synthesis in cancer. Twit Text FOAVip Non-coding RNAs, the cutting edge of histone messages ????RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=26909464 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26909464 #FOAvip English Wikipedia <ref>{{Cite pmid|26909464}}</ref> Non-coding RNAs, the cutting edge of histone messages #MMPMID26909464 Köhn M; Hüttelmaier S RNA Biol 2016[Apr]; 13 (4): 367-72 PMID26909464show ga In metazoan the 3?-end processing of histone mRNAs is a conserved process involving the concerted action of many protein factors and the non-coding U7 snRNA. Recently, we identified that the processing of histone pre-mRNAs is promoted by an additional ncRNA, the Y3-derived Y3** RNA. U7 modulates the association of the U7 snRNP whereas Y3** promotes recruitment of CPSF (cleavage and polyadenylation specific factor) proteins to nascent histone transcripts at histone locus bodies (HLBs) in mammals. This enhances the 3?-end cleavage of nascent histone pre-mRNAs and modulates HLB assembly. Here we discuss new insights in the role of ncRNAs in the spatiotemporal control of histone synthesis. We propose that ncRNAs scaffold the formation of functional protein-RNA complexes and their sequential deposition on nascent histone pre-mRNAs at HLBs. These findings add to the multiple roles of ncRNAs in controlling gene expression and may provide new avenues for targeting histone synthesis in cancer. äNon-coding RNAs, the cutting edge of histone messages (epmc).pdf DeepDyve Pubget Overpricing