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2016 ; 11
(5
): 3075-3080
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English Wikipedia
Apigenin suppresses colorectal cancer cell proliferation, migration and invasion
via inhibition of the Wnt/?-catenin signaling pathway
#MMPMID27123066
Xu M
; Wang S
; Song YU
; Yao J
; Huang K
; Zhu X
Oncol Lett
2016[May]; 11
(5
): 3075-3080
PMID27123066
show ga
Abnormal activation of the Wnt/?-catenin signaling pathway has a significant role
in human tumorigenesis. The search for potential anticancer drugs has included
widespread screening of inhibitors of the Wnt signaling pathway. Recently, one of
the most common flavonoids, apigenin, demonstrated potential anti-tumor effects
on multiple human cancer cell lines, with low cytotoxicity and no mutagenic
activity. However, the association between apigenin and the Wnt/?-catenin
signaling pathway remains to be elucidated. The results of wound healing and
Transwell invasion assays revealed that apigenin was able to significantly
suppress colorectal cancer cell proliferation, migration and invasion in a
dose-dependent manner. An organoid culture assay revealed that apigenin was also
able to suppress the growth of intestinal organoids. Furthermore, apigenin
inhibited ?-catenin/T-cell factor/lymphoid enhancer factor signaling activation,
which was induced by LiCl in a dose-dependent manner. This inhibited ?-catenin
nuclear entry, and therefore the expression of Wnt downstream target genes. In
conclusion, apigenin significantly suppressed colorectal cancer cell
proliferation, migration, invasion and organoid growth by inhibiting the
Wnt/?-catenin signaling pathway.