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10.3892/ol.2016.4404 http://scihub22266oqcxt.onion/10.3892/ol.2016.4404 C4840973!4840973 !27123120     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27123120 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncol+Lett 2016 ; 11 (5 ): 3377-3383 Nephropedia Template TP {{tp|p=27123120 |t=2016. Simvastatin blocks TGF-?1-induced epithelial-mesenchymal transition in human prostate cancer cells |pdf=|usr=}}{{27123120 }} gab.com Text Simvastatin blocks TGF- 1-induced epithelial-mesenchymal transition in human prostate cancer cells JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=27123120 #FOAvip In recent years, the use of statins has been reported to be associated with a reduced risk of prostate cancer (PCa), particularly metastatic PCa. The mechanisms underlying these epidemiological observations are poorly understood. Epithelial-mesenchymal transition (EMT) is a critical initial step and a hallmark for cancer metastasis. In the present study, the relationship between simvastatin and EMT in PCa and the mechanism involved was investigated. It was demonstrated that simvastatin inhibited the EMT as assessed by reduced expression of N-cadherin and vimentin, and increased E-cadherin in TGF-?1 treated DU145 PCa cells. Furthermore, simvastatin inhibited TGF-?1-induced migration and invasion of DU145 cells. The TGF-?1/Smad pathway and non-Smad pathway were investigated in simvastatin-treated DU145 cells. Simvastatin had no effect on TGF-?1-induced phosphorylation of Smad2 and Smad3. In the non-Smad pathway, simvastatin reduced TGF-?1-induced p38 MAPK phosphorylation, but had no effect on TGF-?1-induced Erk1/2 phosphorylation. Simvastatin attenuated TGF-?1-induced EMT, cell migration and invasion in DU145 cells. These effects may have been mediated by the inhibition of p38 MAPK phosphorylation, not through the canonical Smad pathway. Therefore simvastatin may be a promising therapeutic agent for treating PCa. Twit Text FOAVip Simvastatin blocks TGF- 1-induced epithelial-mesenchymal transition in human prostate cancer cells ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=27123120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27123120 #FOAvip English Wikipedia <ref>{{Cite pmid|27123120 }}</ref> Simvastatin blocks TGF-?1-induced epithelial-mesenchymal transition in human prostate cancer cells #MMPMID27123120 Xie F ; Liu J ; Li C ; Zhao Y Oncol Lett 2016[May]; 11 (5 ): 3377-3383 PMID27123120 show ga In recent years, the use of statins has been reported to be associated with a reduced risk of prostate cancer (PCa), particularly metastatic PCa. The mechanisms underlying these epidemiological observations are poorly understood. Epithelial-mesenchymal transition (EMT) is a critical initial step and a hallmark for cancer metastasis. In the present study, the relationship between simvastatin and EMT in PCa and the mechanism involved was investigated. It was demonstrated that simvastatin inhibited the EMT as assessed by reduced expression of N-cadherin and vimentin, and increased E-cadherin in TGF-?1 treated DU145 PCa cells. Furthermore, simvastatin inhibited TGF-?1-induced migration and invasion of DU145 cells. The TGF-?1/Smad pathway and non-Smad pathway were investigated in simvastatin-treated DU145 cells. Simvastatin had no effect on TGF-?1-induced phosphorylation of Smad2 and Smad3. In the non-Smad pathway, simvastatin reduced TGF-?1-induced p38 MAPK phosphorylation, but had no effect on TGF-?1-induced Erk1/2 phosphorylation. Simvastatin attenuated TGF-?1-induced EMT, cell migration and invasion in DU145 cells. These effects may have been mediated by the inhibition of p38 MAPK phosphorylation, not through the canonical Smad pathway. Therefore simvastatin may be a promising therapeutic agent for treating PCa. äSimvastatin blocks TGF-?1-induced epithelial-mesenchymal transition in(epmc).pdf DeepDyve Pubget Overpricing