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10.3892/etm.2016.3147 http://scihub22266oqcxt.onion/10.3892/etm.2016.3147 C4840773!4840773 !27168835     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27168835 &cmd=llinks): Failed to open stream: HTTP request failed! 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Memory-enhancing effect of aspirin is mediated through opioid system modulation in an AlCl(3)-induced neurotoxicity mouse model |pdf=|usr=}}{{27168835 }} gab.com Text Memory-enhancing effect of aspirin is mediated through opioid system modulation in an AlCl(3)-induced neurotoxicity mouse model JO: Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=27168835 #FOAvip Neurodegenerative disorders such as Alzheimers disease (AD) are multifaceted and there are currently a limited number of therapeutic strategies available to treat them. Aspirin is known to act on multiple therapeutic targets and is a successful anti-inflammatory agent in various tissues. The present study aimed to ascertain the performance of aspirin when employed as a therapeutic agent to treat neurodegeneration on novel targets, including opioid system genes, in an AlCl(3)-induced neurotoxicity mouse model. The effects of two doses of aspirin (5 and 20 mg/kg aspirin for 12 days) were investigated in an AlCl(3)-induced neurotoxicity mouse model (150 mg/kg AlCl(3) for 12 days). Neurological improvements were assessed through different behavioral tests and the effects of aspirin on opioid system gene expression levels were assessed by reverse transcription-polymerase chain reaction. Both doses resulted in improvements in cognitive behavior. A 5 mg/kg dose of aspirin was revealed to be effective for spatial memory improvement (7.14±0.84 sec), whilst a 20 mg/kg dose was superior for improving extinction learning (7.63±4.04%). Aspirin (5 mg/kg) also significantly improved contextual memory (48.05±10.6%) when compared with the AlCl(3)-treated group (1.49±0.62%; P<0.001). Aspirin was also observed to significantly decrease ?-opioid receptor expression in the cortex (1.09±0.08 and 1.27±0.08, respectively) at both doses (5 and 20 mg/kg) when compared with the AlCl(3)-treated group (3.69±1.43; P<0.05). Furthermore, aspirin at 5 mg/kg significantly reduced expression of prodynorphin in the cortex (0.57±0.20) when compared with the AlCl(3)-treated group (1.95±0.84; P<0.05). Notably, the effect of aspirin was significant in the cortex but not in the hippocampus. In summary, aspirin was effective in ameliorating the AD-like symptoms via the modulation of opioid systems. However, additional studies are required to determine the long term effects of aspirin on such conditions. Twit Text FOAVip Memory-enhancing effect of aspirin is mediated through opioid system modulation in an AlCl(3)-induced neurotoxicity mouse model ????Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=27168835 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27168835 #FOAvip English Wikipedia <ref>{{Cite pmid|27168835 }}</ref> Memory-enhancing effect of aspirin is mediated through opioid system modulation in an AlCl(3)-induced neurotoxicity mouse model #MMPMID27168835 Rizwan S ; Idrees A ; Ashraf M ; Ahmed T Exp Ther Med 2016[May]; 11 (5 ): 1961-1970 PMID27168835 show ga Neurodegenerative disorders such as Alzheimers disease (AD) are multifaceted and there are currently a limited number of therapeutic strategies available to treat them. Aspirin is known to act on multiple therapeutic targets and is a successful anti-inflammatory agent in various tissues. The present study aimed to ascertain the performance of aspirin when employed as a therapeutic agent to treat neurodegeneration on novel targets, including opioid system genes, in an AlCl(3)-induced neurotoxicity mouse model. The effects of two doses of aspirin (5 and 20 mg/kg aspirin for 12 days) were investigated in an AlCl(3)-induced neurotoxicity mouse model (150 mg/kg AlCl(3) for 12 days). Neurological improvements were assessed through different behavioral tests and the effects of aspirin on opioid system gene expression levels were assessed by reverse transcription-polymerase chain reaction. Both doses resulted in improvements in cognitive behavior. A 5 mg/kg dose of aspirin was revealed to be effective for spatial memory improvement (7.14±0.84 sec), whilst a 20 mg/kg dose was superior for improving extinction learning (7.63±4.04%). Aspirin (5 mg/kg) also significantly improved contextual memory (48.05±10.6%) when compared with the AlCl(3)-treated group (1.49±0.62%; P<0.001). Aspirin was also observed to significantly decrease ?-opioid receptor expression in the cortex (1.09±0.08 and 1.27±0.08, respectively) at both doses (5 and 20 mg/kg) when compared with the AlCl(3)-treated group (3.69±1.43; P<0.05). Furthermore, aspirin at 5 mg/kg significantly reduced expression of prodynorphin in the cortex (0.57±0.20) when compared with the AlCl(3)-treated group (1.95±0.84; P<0.05). Notably, the effect of aspirin was significant in the cortex but not in the hippocampus. In summary, aspirin was effective in ameliorating the AD-like symptoms via the modulation of opioid systems. However, additional studies are required to determine the long term effects of aspirin on such conditions. äMemory-enhancing effect of aspirin is mediated through opioid system m(epmc).pdf DeepDyve Pubget Overpricing