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2016 ; 4
(5
): 605-608
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Changes in the Dickkopf-1 and tartrate-resistant acid phosphatase 5b serum levels
in preschool children with nephrotic syndrome
#MMPMID27123255
Zhang J
; Zeng H
; Fu S
; Shi P
; Wang M
; Guo LI
Biomed Rep
2016[May]; 4
(5
): 605-608
PMID27123255
show ga
The aim of the present study was to investigate the changes in the serum
Dickkopf-1 (DKK-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b) levels
in preschoolers with nephrotic syndrome (NS). A total of 50 preschoolers (3-5
years old) with NS and 20 healthy preschoolers (control group) were enrolled in
the prospective single-center study. The patients with NS received glucocorticoid
treatment and the control group received no treatment. The levels of serum
calcium, phosphorus, TRACP-5b, DKK-1 and 25-hydroxyvitamin D3 were measured at
baseline and at 3 and 6 months in all the subjects. The levels of DKK-1 and
TRACP-5b were significantly higher in the NS group prior to treatment when
compared to the control group (P<0.05), but did not differ significantly between
the two groups following treatment (P>0.05). Therefore, DKK-1 and TRACP-5b can be
used as biomarkers of bone formation and bone resorption, respectively, in the
early evaluation of bone metabolism.