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10.3892/br.2016.631

http://scihub22266oqcxt.onion/10.3892/br.2016.631
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C4840579!4840579 !27123255
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suck abstract from ncbi


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pmid27123255
      Biomed+Rep 2016 ; 4 (5 ): 605-608
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  • Changes in the Dickkopf-1 and tartrate-resistant acid phosphatase 5b serum levels in preschool children with nephrotic syndrome #MMPMID27123255
  • Zhang J ; Zeng H ; Fu S ; Shi P ; Wang M ; Guo LI
  • Biomed Rep 2016[May]; 4 (5 ): 605-608 PMID27123255 show ga
  • The aim of the present study was to investigate the changes in the serum Dickkopf-1 (DKK-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b) levels in preschoolers with nephrotic syndrome (NS). A total of 50 preschoolers (3-5 years old) with NS and 20 healthy preschoolers (control group) were enrolled in the prospective single-center study. The patients with NS received glucocorticoid treatment and the control group received no treatment. The levels of serum calcium, phosphorus, TRACP-5b, DKK-1 and 25-hydroxyvitamin D3 were measured at baseline and at 3 and 6 months in all the subjects. The levels of DKK-1 and TRACP-5b were significantly higher in the NS group prior to treatment when compared to the control group (P<0.05), but did not differ significantly between the two groups following treatment (P>0.05). Therefore, DKK-1 and TRACP-5b can be used as biomarkers of bone formation and bone resorption, respectively, in the early evaluation of bone metabolism.
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