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10.3892/mco.2016.806 http://scihub22266oqcxt.onion/10.3892/mco.2016.806 C4840568!4840568 !27123272     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27123272 &cmd=llinks): Failed to open stream: HTTP request failed! 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An 80-gene set to predict response to preoperative chemoradiotherapy for rectal cancer by principle component analysis |pdf=|usr=}}{{27123272 }} gab.com Text An 80-gene set to predict response to preoperative chemoradiotherapy for rectal cancer by principle component analysis JO: Mol Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27123272 #FOAvip Preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer not only improves the postoperative local control rate, but also induces downstaging. However, it has not been established how to individually select patients who receive effective preoperative CRT. The aim of this study was to identify a predictor of response to preoperative CRT for locally advanced rectal cancer. This study is additional to our multicenter phase II study evaluating the safety and efficacy of preoperative CRT using oral fluorouracil (UMIN ID: 03396). From April, 2009 to August, 2011, 26 biopsy specimens obtained prior to CRT were analyzed by cyclopedic microarray analysis. Response to CRT was evaluated according to a histological grading system using surgically resected specimens. To decide on the number of genes for dividing into responder and non-responder groups, we statistically analyzed the data using a dimension reduction method, a principle component analysis. Of the 26 cases, 11 were responders and 15 non-responders. No significant difference was found in clinical background data between the two groups. We determined that the optimal number of genes for the prediction of response was 80 of 40,000 and the functions of these genes were analyzed. When comparing non-responders with responders, genes expressed at a high level functioned in alternative splicing, whereas those expressed at a low level functioned in the septin complex. Thus, an 80-gene expression set that predicts response to preoperative CRT for locally advanced rectal cancer was identified using a novel statistical method. Twit Text FOAVip An 80-gene set to predict response to preoperative chemoradiotherapy for rectal cancer by principle component analysis ????Mol Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27123272 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27123272 #FOAvip English Wikipedia <ref>{{Cite pmid|27123272 }}</ref> An 80-gene set to predict response to preoperative chemoradiotherapy for rectal cancer by principle component analysis #MMPMID27123272 Empuku S ; Nakajima K ; Akagi T ; Kaneko K ; Hijiya N ; Etoh T ; Shiraishi N ; Moriyama M ; Inomata M Mol Clin Oncol 2016[May]; 4 (5 ): 733-739 PMID27123272 show ga Preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer not only improves the postoperative local control rate, but also induces downstaging. However, it has not been established how to individually select patients who receive effective preoperative CRT. The aim of this study was to identify a predictor of response to preoperative CRT for locally advanced rectal cancer. This study is additional to our multicenter phase II study evaluating the safety and efficacy of preoperative CRT using oral fluorouracil (UMIN ID: 03396). From April, 2009 to August, 2011, 26 biopsy specimens obtained prior to CRT were analyzed by cyclopedic microarray analysis. Response to CRT was evaluated according to a histological grading system using surgically resected specimens. To decide on the number of genes for dividing into responder and non-responder groups, we statistically analyzed the data using a dimension reduction method, a principle component analysis. Of the 26 cases, 11 were responders and 15 non-responders. No significant difference was found in clinical background data between the two groups. We determined that the optimal number of genes for the prediction of response was 80 of 40,000 and the functions of these genes were analyzed. When comparing non-responders with responders, genes expressed at a high level functioned in alternative splicing, whereas those expressed at a low level functioned in the septin complex. Thus, an 80-gene expression set that predicts response to preoperative CRT for locally advanced rectal cancer was identified using a novel statistical method. äAn 80-gene set to predict response to preoperative chemoradiotherapy f(epmc).pdf DeepDyve Pubget Overpricing