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10.3892/etm.2016.3149

http://scihub22266oqcxt.onion/10.3892/etm.2016.3149
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C4840564!4840564!27168822
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suck abstract from ncbi


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pmid27168822      Exp+Ther+Med 2016 ; 11 (5): 1889-92
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  • Novel therapy for anti-glomerular basement membrane disease with IgA nephropathy: A case report #MMPMID27168822
  • XU D; WU J; WU J; XU C; ZHANG Y; MEI C; GAO X
  • Exp Ther Med 2016[May]; 11 (5): 1889-92 PMID27168822show ga
  • Anti-glomerular basement membrane (GBM) disease is characterized by circulating anti-GBM antibodies and deposition of these antibodies in the renal GBM. Renal involvement in anti-GBM is more severe when compared with other types of immune-mediated glomerulonephritis, and the majority of patients manifest progressive renal failure, leading to end-stage renal disease. In a limited number of cases, anti-GBM disease has been shown to be accompanied with other immune-mediated glomerulonephritis. The present study reported the case of a 50-year-old female patient presenting with rapidly progressive glomerulonephritis, who was diagnosed with anti-GBM disease with IgA nephropathy. The patient achieved a relatively good therapeutic outcome with administration of corticosteroids plus mycophenolate mofetil (MMF), which may prove to be a novel treatment option for this rare disease; however, the exact underlying mechanism requires further in-depth investigation.
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